Edward Randell

Professor of Laboratory Medicine PhD (Memorial), DCC, FCACB

Lab Medicine


Dr. Edward Randell is Chief of Clinical Biochemistry with Eastern Health and Professor with the Faculty of Medicine in the Division of Laboratory Medicine. Dr. Randell received his B.Sc. and PhD in Science (Department of Biochemistry) at Memorial University. He received a Diploma in Clinical Chemistry from the University of Toronto and is a Certified Clinical Chemist and Fellow of the Canadian Academy for Clinical Biochemistry. He received his Six Sigma Black Belt (Process improvement) in August, 2017.

He is actively involved in both national and international organizations focusing on laboratory medicine, including recent involvement as a full member of the International Federation of Clinical Chemistry and Laboratory Medicine Committee on Clinical Laboratory Management, since 2016 ( http://www.ifcc.org/ifcc-education-division/emd-committees/c-clm/).

He has co-edited and co-chapter author on one book on leadership basics for clinical laboratory professionals (ISBN 978-88-87772-10-4), and has published over 100 articles in international peer-reviewed journals.

His main research interests relate to:

1. Discovery and characterization of biochemical markers of disease.
2. Evidence-based laboratory medicine and utilization management.
3. Process Improvement.


Listing of peer-reviewed publications for the past 5 years:

Huang, Y., Campbell, E., Colbourne, B., Power, J., & Randell, E. (2019). User competency is still a major factor affecting analytical performance of glucose meters in patient service. Clinical biochemistry 63, 66-71.

Gao, X., Tian, Y., Randell, E., Zhou, H., & Sun, G. (2019). Unfavorable associations between serum Trimethylamine N-oxide and L-carnitine levels with components of metabolic syndrome in the Newfoundland population. Frontiers in Endocrinology, 10, 168.

Huang, Y., Tian, Y., Likhodii, S., & Randell, E. (2019). Baseline urinary KIM-1 concentration in detecting acute kidney injury should be interpreted with patient pre-existing nephropathy. Practical Laboratory Medicine, e00118.

Randell, E.W. & Yenice, S. (2019) Delta Checks in the Clinical Laboratory. Crit. Rev. Clin. Lab. Med. 11:1-23.

Robinson, J. L., McBreairty, L. E., Randell, E. W., Harding, S. V., Bartlett, R. K., Brunton, J. A., & Bertolo, R. (2018). Betaine or folate can equally furnish remethylation to methionine and increase transmethylation in methionine-restricted neonates. The Journal of Nutritional Biochemistry. 59:129-135

Rockel, J. S., Zhang, W., Shestopaloff, K., Likhodii, S., Sun, G., Furey, A., ... & Kapoor, M. (2018). A classification modeling approach for determining metabolite signatures in osteoarthritis. PloS one, 13(6), e0199618.

Randell, E. W., Short, G., Lee, N., Beresford, A., Spencer, M., Kennell, M., ... & Parry, D. (2018). Autoverification process improvement by Six Sigma approach: clinical chemistry & immunoassay. Clinical biochemistry, 55, 42-48.

Randell, E. W., Short, G., Lee, N., Beresford, A., Spencer, M., Kennell, M., ... & Parry, D. (2018). Strategy for 90% autoverification of clinical chemistry and immunoassay test results using six sigma process improvement. Data in brief, 18, 1740-1749.

Hu, T., Oksanen, K., Zhang, W., Randell, E., Furey, A., Sun, G., & Zhai, G. (2018). An evolutionary learning and network approach to identifying key metabolites for osteoarthritis. PLoS computational biology, 14(3), e1005986.

Gao, X., Randell, E., Zhou, H., & Sun, G. (2018). Higher serum choline and betaine levels are associated with better body composition in male but not female population. PloS one, 13(2), e0193114.

MacMillan, L., Tingley, G., Young, S. K., Clow, K. A., Randell, E. W., Brosnan, M. E., & Brosnan, J. T. (2018). Cobalamin Deficiency Results in Increased Production of Formate Secondary to Decreased Mitochondrial Oxidation of One-Carbon Units in Rats. The Journal of nutrition, 148(3), 358-363.

Zhai, G., Randell, E. W., & Rahman, P. (2018). Metabolomics of osteoarthritis: emerging novel markers and their potential clinical utility. Rheumatology. 57(12):2087-2095 https://doi.org/10.1093/rheumatology/kex497

Hu, T., Oksanen, K., Zhang, W., Randell, E., Furey, A., & Zhai, G. (2018, April). Analyzing Feature Importance for Metabolomics Using Genetic Programming. In European Conference on Genetic Programming (pp. 68-83). Springer, Cham. https://doi.org/10.1007/978-3-319-77553-1_5

Kavsak, P. A., Worster, A., Oliver, R., Clark, L., Parry, D., Randell, E., ... & Jaffe, A. S. (2018). Variability between reagent lots for high-sensitivity cardiac troponin I may affect performance of early-rule out strategies. Canadian Journal of Cardiology. 2018 34(2):209-e5.

Shuo Li, Yu-Ming Xu, Hong Zheng, Edward Randell, Hai-Zheng Wang, Jianxun Cui, Guang Sun, Guangju Zhai, Fei-Yu Han, Ya-Gang Xie. (2017) A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population. International Journal of Genetics and Genomics. 2017; 5(1): 14-18.

Gregory, D. M., Twells, L. K., Lester, K. K., Midodzi, W. K., Pedersen, M. R., Pace, D., ... & Kovacs, C. S. (2017). Preoperative and Postoperative Assessments of Biochemical Parameters in Patients with Severe Obesity Undergoing Laparoscopic Sleeve Gastrectomy. Obesity surgery 28(8):2261-2271.

Booth, R. A., McCudden, C. R., Balion, C. M., Blasutig, I. M., Bouhtiauy, I., Rodriguez-Capote, K., ... & Hauff, K. (2017). Candidate recommendations for protein electrophoresis reporting from the Canadian Society of Clinical Chemists Monoclonal Gammopathy Working Group. Clinical biochemistry. 2017 51:10-20.

Randell, E. W., Twells, L. K., Gregory, D. M., Lester, K. K., Daneshtalab, N., Dillon, C., ... & Boone, D. (2017). Pre-operative and post-operative changes in CRP and other biomarkers sensitive to inflammatory status in patients with severe obesity undergoing laparoscopic sleeve gastrectomy. Clinical biochemistry. 2017 52, 13-19.

Catomeris, P., Baxter, N. N., Boss, S. C., Paszat, L. F., Rabeneck, L., Randell, E., ... & Tinmouth, J. (2017). Effect of Temperature and Time on Fecal Hemoglobin Stability in 5 Fecal Immunochemical Test Methods and One Guaiac Method. Archives of pathology & laboratory medicine, 142(1), 75-82.

Chan, Pak Cheung, Yu Chen, and Edward W. Randell. "On the path to evidence-based reporting of serum protein electrophoresis patterns in the absence of a discernible monoclonal protein-A critical review of literature and practice suggestions." Clinical biochemistry (2017). 2017 51:29-37.

Zhang, W., Randell, E. W., Sun, G., Likhodii, S., Liu, M., Furey, A., & Zhai, G. (2017). Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes. PloS one, 12(9), e0184105.

Gao, X., Wang, Y., Randell, E., Pedram, P., Yi, Y., Gulliver, W., & Sun, G. (2016). Higher Dietary Choline and Betaine Intakes Are Associated with Better Body Composition in the Adult Population of Newfoundland, Canada. PloS one, 11(5), e0155403.

Gao, X., Zhang, W., Wang, Y., Pedram, P., Cahill, F., Zhai, G., Randell, E., Gulliver, W. and Sun, G(2016). Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals. Nutrition & Metabolism. 2016;13:33. doi:10.1186/s12986-016-0095-9.

Robinson, J. L., McBreairty, L. E., Randell, E. W., Brunton, J. A., & Bertolo, R. F. (2016). Restriction of dietary methyl donors limits methionine availability and affects the partitioning of dietary methionine for creatine and phosphatidylcholine synthesis in the neonatal piglet. The Journal of Nutritional Biochemistry, 35, 81-86.

Robinson, J. L., Bartlett, R. K., Harding, S. V., Randell, E. W., Brunton, J. A., & Bertolo, R. F. (2016). Dietary methyl donors affect in vivo methionine partitioning between transmethylation and protein synthesis in the neonatal piglet. Amino Acids 48:2821-2830.

Zhang, W., Sun, G., Likhodii, S., Aref-Eshghi, E., Harper, P. E., Randell, E., ... & Zhai, G. (2016). Metabolomic analysis of human synovial fluid and plasma reveals that phosphatidylcholine metabolism is associated with both osteoarthritis and diabetes mellitus. Metabolomics, 12(2), 1-10.

Hu, T., Zhang, W., Fan, Z., Sun, G., Likhodi, S., Likhodi, S., Randell, E., & Zhai, G. (2016) Metabolics Differential Corrrelation Network Analysis of Osteroarthritis. Pac. Symp. Biocomput. 21:120-31.

Zhang W, Sun G, Aitken D, Likhodii S, Liu M, Martin G, Furey A, Randell E, Rahman P, Jones G, Zhai G. (2016) Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis. Rheumatology (Oxford). 55(9):1566-74. doi: 10.1093/rheumatology/kew207.

Zhang W, Sun G, Likhodii S, Liu M, Aref-Eshghi E, Harper PE, Martin G, Furey A, Green R, Randell E, Rahman P, Zhai G. (2016) Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients. Osteoarthritis Cartilage. 2016 May;24(5):827-34. doi: 10.1016/j.joca.2015.12.004. Epub 2015 Dec 18

Pall, H., Newhook, L. A., Aaron, H., Curtis, J., & Randell, E. (2015). Young Age at Diagnosis of Type 1 Diabetes Is Associated with the Development of Celiac Disease—Associated Antibodies in Children Living in Newfoundland and Labrador, Canada. Children, 2(4), 403-411.

Araújo PA, Thomas D, Sadeghieh T, Bevilacqua V, Chan MK, Chen Y, Randell E, Adeli K (2015). CLSI-based transference of the CALIPER database of pediatric reference intervals to Beckman Coulter DxC biochemical assays. Clinical biochemistry. Clin Biochem.< http://www.ncbi.nlm.nih.gov/pubmed/26070714> 48;13:870-880 pii: S0009-9120(15)00215-5. doi: 10.1016/j.clinbiochem.2015.06.002

Fairbridge NA, Southall TM, Ayre DC, Komatsu Y, Raquet PI, Brown RJ, Randell E, Kovacs CS, Christian SL. (2015) Loss of CD24 in Mice Leads to Metabolic Dysfunctions and a Reduction in White Adipocyte Tissue. PLoS One. 2015 Nov 4;10(11):e0141966. doi: 10.1371/journal.pone.0141966. eCollection 2015

Banoub JH, Demian WL, Piazzetta P, Sarkis G, Kanawati B, Lafont D, Laurent N, Vaillant C, Randell E, Giorgi G, Fridgen TD. (2015) The in situ gas-phase formation of a C-glycoside ion obtained during electrospray ionization tandem mass spectrometry. A unique intramolecular mechanism involving an ion-molecule reaction. Rapid Commun Mass Spectrom. 2015 Oct 15;29(19):1717-32. doi: 10.1002/rcm.7269.

McBreairty, L. E., Robinson, J. L., Harding, S. V., Randell, E. W., Brunton, J. A., & Bertolo, R. F. (2016). Betaine is as effective as folate at re-synthesizing methionine for protein synthesis during moderate methionine deficiency in piglets. European journal of nutrition,55:2423-2430.

Higgins, V., Chan, M. K., Nieuwesteeg, M., Hoffman, B. R., Bromberg, I. L., Gornall, D., Randell E,. & Adeli, K. (2016). Transference of CALIPER pediatric reference intervals to biochemical assays on the Roche cobas 6000 and the Roche Modular P. Clinical biochemistry 2016 ;49:139-149.

Demian, W. L., Collins, S., Fowler, C., McGrath, J., Antle, S., Moores, Z., ... & Randell, E. (2015). Evaluation of the analytical performance of the novel NS-Prime system and examination of temperature stability of fecal transferrin compared with fecal hemoglobin as biomarkers in a colon cancer screening program. Practical Laboratory Medicine, 2, 29-36.

Zhang, W., Likhodii, S., Aref-Eshghi, E., Zhang, Y., Harper, P. E., Randell, E., ... & Zhai, G. (2015). Relationship Between Blood Plasma and Synovial Fluid Metabolite Concentrations in Patients with Osteoarthritis. The Journal of rheumatology, 42(5), 859-865.

Zhang W, Likhodii S, Zhang Y, Aref-Eshghi E, Harper PE, Randell E, Green R, Martin G, Furey A, Sun G, Rahman P, Zhai G (2014). Classification of osteoarthritis phenotypes by metabolomics analysis. BMJ Open Nov 19;4(11):e006286. doi: 10.1136/bmjopen-2014-006286.

Williams CE, Curtis BM, Randell EW, Foley RN, Parfrey PS (2014). Cardiac biomarkers and health-related quality of life in new hemodialysis patients without symptomatic cardiac disease. Canadian Journal of Kidney Health and Disease, 1(1), 16.

Demian WLL, Kotari N, Shiao TC, Randell E, Roy R, Banoub JH. Direct targeted glycation of the free sulfhydryl group of cysteine residue (Cys-34) of BSA. Mapping of the glycation sites of the anti-tumor Thomsen-Friedenreich neoglycoconjugate vaccine prepared by Michael addition reaction. J Mass Spectrom. 2014 Dec;49(12):1223-33. doi: 10.1002/jms.3448.

Lamarre SG, MacMillan L, Morrow GP, Randell E, Pongnopparat T, Brosnan ME, Brosnan JT. An isotope-dilution, GC–MS assay for formate and its application to human and animal metabolism. Amino acids 2014 46(8):1885-1891.

Demian WL, Jahouh FM, Stansbury D, Randell E, Brown RJ, Banoub JH. Characterizing changes in snow crab (Chionoecetes opilio) cryptocyanin protein during molting using matrix-assisted laser desorption/ionization mass spectrometry and tandem mass spectrometry. Rapid Commun Mass Spectrom. 2014 Feb 28;28(4):355-69. doi: 10.1002/rcm.6788.

Kolypetri P, Randell E, Van Vliet BN, Carayanniotis, G. High salt intake does not exacerbate murine autoimmune thyroiditis. Clinical & Experimental Immunology 2014, 176(3), 336-340.

Cahill F, Ji Y, Wadden D, Amini P, Randell E, Vasdev, S, Sun, G. The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study. PloS one. 2014 9(4), e95235.