Assistant Professor - Environmental Science (Chemistry)

Director, Aging Research Centre-Newfoundland and Labrador

Phone: (709) 639-4800

Email: karen.doody@mun.ca

Social Media/LinkedIn: LinkedIn

 

Research interests/expertise

• Aging; interaction of environment, aging, and disease development
• Environmental toxins and their effect on cancer and autoimmune disease
• Functional foods
• Autoimmune disease (focus on rheumatoid arthritis)
• Cancer
• Translational Medicine
• Protein tyrosine phosphatases

Teaching

• CHEM2400
• CHEM2440
• BIOC1430 
• BIOL3053
• CHEM1200
• ENVS3260 

 

Publications:

• Fillier TA, Doody KM, Pham TH, Aubry I, Tremblay ML, Cheema SK, Blundell J, Thomas RH. Brief exposure of neuronal cells to levels of short chain fatty acids observed in human systemic circulation impair the cell lipid metabolism resulting in associated cell death by apoptosis. (2022) Scientific Reports. 12(1): 14355.
• Svensson M, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Zi R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall A-K, Stanford SM, Bottini N. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. (2020) Science Advances 6(26):eaba4353.
• Manful CF, Vidal NP, Pham TH, Nadeem M, Wheeler E, Hamilton MC, Doody KM, Thomas RH. Unfiltered beer-based marinades reduced exposure to carcinogens and suppressed conjugated fatty acid oxidation in grilled meats. (2020) Food Control. 111:107040.
• Manful CF, Vidal NP, Pham TH, Nadeem M, Wheeler E, Hamilton MC, Doody KM, Thomas RH. Rapid determination of heterocyclic amines in ruminant meats using accelerated solvent extraction and ultra-high performance liquid chromatograph-mass spectrometry. (2019) MethodsX. 6:2686-2697.
• Manful CF, Vidal NP, Pham TH, Nadeem M, Wheeler E, Hamilton MC, Doody KM, Thomas RH. Dataset on improved nutritional quality and safety of grilled marinated and unmarinated ruminant meat using novel unfiltered beer-based marinades. (2019) Data Brief. 27:104801.
• Svensson M, Doody KM, Schmiedel B, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N. Loss-of-function of PTPN2 promotes pathogenic loss of FoxP3+ in RORgt+ Tregs. (2019) Journal of Clinical Investigation. 129(3):1193-1210. *Paper highlighted in Nature Reviews Rheumatology. 2019 15:127.
• Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V, Sacchetti C, Zoccheddu M, Lonic A, Li X, Boyle DL, Hammaker D, Meng TC, Liu L, Corr M, Stanford SM, Lewis M, Wang W, Firestein GS, Khew-Goodall Y, Pitzalis C, Bottini N. PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes. (2019). Annals of the Rheumatic Diseases. 78(5): 600–609.
• Pham TH, Vidal NP, Manful CF, Fillier TA, Pumphrey RP, Doody KM, Thomas RH. Moose and Caribou as Novel Sources of Functional Lipids: Fatty Acid Esters of Hydroxy Fatty Acids, Diglycerides and Monoacetyldiglycerides. (2019) Molecules. 24(2).
• Doody KM, Bottini N, Firestein GS. (2017) Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes. Epigenomics. 9(4):479-492.
• Doody KM, Bottini N. (2016) Chondrocyte clocks make cartilage time-sensitive material. Journal of Clinical Investigation. 126(1):38-9.
• Doody, KM, Stanford, SM, Sacchetti, C, Svensson, MND, Coles, CH, Mitakidis, N, Kiosses, WB, Bartok, B, Fos, C, Cory, E, Sah, R. L, Liu-Bryan, R, Boyle, D. L, Arnett, HA, Mustelin, T, Corr, M, Esko, JD, Tremblay, ML, Firestein, GS, Aricescu, AR, and Bottini, N. (2015) Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Science Translational Medicine. 7(288):2. *Paper highlighted in Nature Reviews Rheumatology 2015 11(7):381; this work was awarded the 2016 Lee C. Howley Sr. Prize for Arthritis Scientific Research
• Doody KM, Bottini N. (2014) "PEST control": regulation of molecular barcodes by tyrosine phosphatases. Cell Research. 24(9):1027-8.
• Bourdeau A, Trop S, Doody KM, Dumont DJ, Tremblay ML. (2013) Inhibition of T cell protein tyrosine phosphatase enhances interleukin-18- dependent hematopoietic stem cell expansion. Stem Cells. 31(2): 293- 304.
• Doody KM, Bussières-Marmen S, Li A, Paquet M, Henderson JE, Tremblay ML. (2012) T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice. Arthritis & Rheumatology 64(3): 752-61 *Paper highlighted in Nature Reviews Rheumatology 2011 7(12):683.
• Hassan, S-W, Doody, KM, Hardy, S, Uetani, N, Cournoyer, D, Tremblay, ML. (2010) Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse. PLoSONE. 5(1): e8868.
• Heinonen, KM*, Bourdeau, A*, Doody, KM*, and Tremblay, M. L. (2009) Protein tyrosine phosphatases PTP-1B and TC-PTP play nonredundant roles in macrophage development and IFN-gamma signaling. PNAS. 106 (23): 9368-9374. *co-first authors
• Doody KM, Bourdeau A, and Tremblay ML. (2009) T cell protein tyrosine phosphatase is a key regulator in immune cell signaling: Lessons from the knockout mouse model and implications in human disease. Immunological Reviews. 228: 325-341.
• Rafei M, Hiseh J, Fortier S, Li M, Yuan S, Birman E, Forner K, Boivin MN, Doody K, Tremblay M, Annabi B, Galipeau J. (2008) Mesenchymal stromal cell derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction. Blood. 112(13): 4991-8.
• Stuible M*, Doody KM*, and Tremblay ML. (2008) PTP1B and TC-PTP: regulators of transformation and tumorigenesis. Cancer & Metastasis Reviews. 27(2): 215-30. *co-first authors
• Bourdeau A, Dubé N, Heinonen KM, Théberge J.-F, Doody KM, and Tremblay ML. (2007) TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-γ. Blood. 109 (10): 4220-8.

 

Awards and Recognitions

• Lee C. Howley Sr. Prize for Arthritis Scientific Research (Arthritis Foundation) (2016)
• Canadian Institutes of Health Research Postdoctoral Fellowship (2011- 2014)
• McGill Integrated Cancer Research Training Program Studentship (2010)
• McGill Faculty of Medicine Internal Fellowship/George G. Harris Fellowship in Cancer Research (2009)
• McGill University Principal’s Graduate Fellowship (2008-2009)
• McGill University Cancer Consortium Training Grant in Cancer Research (CIHR) renewal (2005-2006)