Biology 4250 - Evolutionary Genetics

Steven M. Carr
Dr. Steven M. Carr

Department of Biology
Memorial University of Newfoundland
    
(
University Diary)
45 Arctic Ave
St. John's NL A1C 5S7, Canada
  e-mail: scarr@mun.ca



    Biol4250 Course Outline updated 28 August 2024

   
Optional Text: G-P Sætre & M Ravient (2019) Evolutionary Genetics: Concepts, Analysis, and Practice [ S&R 2019 ]
      
     MATLAB software

    
MEGA X (Molecular Evolutionary Genetics Analysis) software

Other web pages of interest:

      Genetic Research in Carr lab
      Biol2250 - Principles of Genetics for Bio4250
      Biol2900 - Principles of Systematics & Evolution   
      Biol3950 - Fundamentals of Biotechnology

      Biol4241 - Advanced Genetics 
      Biol4270 - History of Biology                                      


Click here to e-mail me questions, comments, or suggestions.
    Please include '4250' in the subject line


Lectures:         Tu Th             0900 - 1015   Chem-3053
Labs:                Th                  1400 - 1700   CSF Biology Office
    
Office Hours:  Tu Th             1030 - 1130    CSF-4342

            On the importance of office hours (NPR, Oct 2019)

Course lecture notes:

.
Week
Lectures
S & R (2019)
Topic
Last
Revised
Lab
Date
Lab Materials
1
05 Sept

Introduction;
 background quiz
30 Aug 2024
05 Sept 2024
Lab Exercise: DNA structure (02 Sept 2024);
 Install MATLAB; Install MEGA
1 & 2
10, 12 Sept

Allele & Genotype frequencies; Hardy-Weinberg Theorem 30 Aug 2024 12 Sept 2024 Statistical Hypothesis Testing; Chi-square test
Biol4250 Chi-Square & G test Workbook
(2024 Sept 18)
;
Lab Exercises: Testing Hardy-Weinberg expectations (2024 Sept 12)
3
17, 19 Sept

Darwin's Theory of Natural Selection
30 Aug 2024 19 Sept 2024 Workbook for Natural selection exercises (revised 2024 Sept 25);
Lab Exercise:
Natural Selection in ecological genetics (2024 Sept 25)

4
24 & 26 Sept
4.2; 5.2
The General Theory of Natural Selection
08 Aug 2024 26 Sept 2024
 Workbook for Natural Selection in variable environments (revised 2024 Oct 09);
Lab Exercise: Natural Selection in variable environments (2024 Oct 03)


Monday, 30 Sept

National Day of Truth & Reconciliation

30 Sept
5 01, 03, 08 Oct
Alternative Models of Natural Selection 04 Oct 2024 03 Oct 2024
Natural Selection under other conditions (revised 2024 Oct 10);
Lab Exercise: Additive, Genic, & Haploid Selection (2024 Oct 10)
Estimation of Selection Coefficients (2024 Sept 18);

6
10 Oct

Fitness, Adaptation, & Selection in Natural Populations
10 Oct 2024
Complete Natural Selection exercises

14-15 Oct

Thanksgiving; Fall Break


No Lecture, Oct 15

17 Oct

Midterm Exam questions

17 Oct 2024
Midterm in Lecture slot [Thursday is Tuesday]
7
22, 24 Oct
1.3; 2 Fitness, Adaptation, & Selection in Natural Populations (Cont'd)
08 Aug 2024 24 Oct 2024 Lab exercise: Migration / Selection in Water Snakes
 Worksheet
for m
8
29, 31 Oct
1.2; 2
Natural Selection in equilibrium with MutationMigration; Inbreeding
08 Aug 2024 31 Oct 2024 Lab Exercise:
Worksheet








9
05, 07 Nov
2.2; 3.4; 4.4
Mendel's Century (1901 - 2024) 08 Aug 2024 07 Nov 2024 Data sets for allozyme, DNA, Micro-satellite analysis (TBA)
10 11 Nov
Remembrance Day
11 Nov 2024

11
12, 14, Nov
2; 3.3,4,5
Genetic Drift;
Selection & Genetic Drift in Finite Populations;
11 Sept 2024 14 Nov 2024 WriFish.m script ; MATLAB app (2020 Oct 29);
Lab Exercise: Natural Selection & Genetic Drift (2024 Nov 14)
12 19, 21 Nov 3.2,3 Molecular Phylogeography:
Genetic variation in time & space
08 Aug 2024 21 Nov 2024 Lab Exercise: F-statistics & Population Structure (2024 Nov 18);
F-Statistics worksheet for F-statistics (2024 Nov 20)
13
26, 28 Nov
8
Molecular Systematics: Phylogenetic reconstruction [Review] 08 Aug 2024 28 Nov
2024
Download MEGA:
Lab Exercise: Molecular Evolutionary Genetics Analysis (2021 Nov 25)
Final


FINAL EXAM: Monday, 09 Dec, 0900-1100
Sample questions

Monday, 09 Dec
0900 - 1100
Expected time from previous years


N&S (2013)
Additional Material from Nielsen & Slatkin (2013)





3, 4
Coalescent Theory; Selective Neutrality




5
Population History & Demography




ACKNOWLEDGMENTS - sources for images

 I acknowledge that the lands on which this work is presented are situated are in the traditional territories of diverse Indigenous groups, and I acknowledge with respect the diverse histories and cultures of the Beothuk, Mi'kmaw, Innu, and Inuit of this province.

Site last modified 18 November 2024
This page was first published on 20 August 2017

Copyright statement:
The lectures, displays, and all material delivered or provided in Biol4250 - Evolutionary Genetics © Steven M Carr, including any visual or audio recording thereof, are subject to copyright owned by Steven M Carr.
It is prohibited
to record, copy, or share by any means, in any format, openly or surreptitiously, in whole or in part, in the absence of express written permission from Steven M Carr, any of the lectures, displays, or materials provided or published in any form during or from this course.


Dedicated to Norman Borlaug (1914 - 2009), Geneticist, Nobel Peace Laureate 1970, & Friend of the People of the Earth
                        & to Dave Wake (1936 - 2021), Evolutionary Biologist & Teacher extraordinaire


 All text material © 2024 by Steven M Carr