New Perspectives from Developmental Biology
Previously:
Evolution
is the transformation of adult morphologies
We visualize fish "morphing" to
lungfish
E.g.,
Reorganization
of
biomaterials
(e.g., changes in protein amino
acid
sequences)
Now:
Evolution
is the modification of developmental (embryonic) ontogeny
Developmental programs serve as "blueprints"
E.g.,
alteration
of
gene regulation (where / when / how much gene
product?)
Can small, quantitative changes lead to large, qualitative changes?
Same program with different parameters
can generate unexpected results
TURTLES
program draws pictures: square
triangle five-pointed
star
Dawkins "Blind
Watchmaker"
Nine-parameter
pattern
program
produces
"biomorphs"
resembling
living organisms
Raup (1962) four-parameter
model
for
gastropod snail shell coiling
"Real" snails occupy one corner of 4-D
space
Many theoretically possible patterns haven't evolved (yet)
D'Arcy Thompson (1926)
"coordinate transformation"
One
fish: pufferfish
sunfish
by positive deformation of tail region
(two fish) (red fish)
(blue fish)
See also Dawkins' "The Blind Watchmaker"
program
Allometric
Equation:
Let y = mxa where x
& y are trait measures
form of equation implies non-linear growth relationship
if
x
is a general size measure and y = 0 when x = 0:
Then ln(y)
= a ln(x) and
a = allometric
coefficient
proportional change of x with respect to y
if
a = 1 then y is proportional to x : no allometry, y
is
isometric
wrt x
if
a > 1 then y grows faster than x (positive
allometry)
Ex.: in humans, legs grow faster
than
torso
if
a < 1 then y grows slower than x (negative
allometry)
Ex.: in humans, head grows
slower
than torso
The allometric
coefficient
can be shown to be
variable, heritable, & adaptive selectable
Theory of
Heterochrony:
The end-point of
ontogeny
can be altered
by
selection on initial parameters of development:
allometric relationship
relative timing: change in
onset & offset of developmental events
Four processes are recognized:
Acceleration:
relative growth rate changes
faster (a increases)
Neoteny:
relative growth rate change more
slowly (a decreases)
Hypermorphosis:
relative growth rate is
prolonged
Progenesis:
relative growth rate is fore-shortened
Progenesis
and
/
or
Neoteny
produce
Paedomorphosis
("child form"):
retention of juvenile characteristics into adult (reproductive)
organisms
Hypermorphosis
and
/
or
Acceleration
produce Peramorphosis
("elder form"):
exaggeration of adult characteristics in larger organisms
Hypermorphosis can be produced by positive
allometry & delayed offset
What are the
evolutionary consequences of selection to increase body size?
[Remember that Cope's Rule
says this is a common trend]
Ex.:
Irish
Elk (Megaloceros) was largest deer ever: 14'
antler rack
Previously:
a
case
of
Orthogenesis:
An
evolutionary
trend
continued
past
the point of functionality
Now:
Antlers
are
positively
allometric
wrt body size
Irish
Elk
antlers
are
expected
size for a deer of its (large) size
At
other
extreme,
miniature
neotropical
deer have "spike"
antlers
Ex.: Horse
evolution
from Eocene Hyracotherium
("Eohippus")
Recent Equus
hypsodont
dentition is positively allometric wrt skull length
facial
portion of skull is positively allometric wrt body size
Progenesis can be produced by negative
allometry & early offset
What are the
consequences
of selection on age / size of sexual maturity?
In many species, time of metamorphosis is size-dependant
Ex.:
Ascidians
(Urochordata)
metamorphose
from
a
motile
juvenile sessile
adult "sea squirt"
Small advancement of age of sexual maturity
produces
functional
gonads
in
a
pre-metamorphosed (motile) form
Garstang
Hypothesis:
Chordates
evolved
from
motile
juvenile
urochordates with a notochord
Evidence:
Larvacea are a motile
group
of "sea squirts"
Ex.:
Thorius
salamanders are smallest vertebrates (adults are ~1 cm long)
Limb structures are variable, new arrangements as adaptations are
possible
Skull structure simplified, roofing bones greatly reduced
In many species, sexual maturity is achieved at some definite age;
somatic
growth
rate
may
be
limited by environmental conditions.
Ex.:
Ambystoma
(tiger salamander) has external gills in aquatic juvenile stage,
Metamorphoses into terrestrial adult with internal gills.
Metamorphosis is triggered by thyroid growth hormone (thyroxin)
"Axolotl"
(Aztec)
lives in high Mexican lakes (cold & low [I2])
Achieves sexual maturity as aquatic form with external gills.
Axolotls fed thyroid extract
metamorphose into Ambystoma
same
species
Developmental
shift
may
be
"fixed"
evolutionarily as between-species
difference
Among
salamanders (Amphibia: Caudata)
adult
Eurycea resembles
juvenile
Typhlotriton.
Typhlomulge & Gyrinophilus (cave salamanders) are
permanently
aquatic.
Amphiuma
(giant salamander)
is a separate family (Amphiumidae).
Ex.:
Homo
appears to be a neotenic ape.
Mandibular portion of human skull grows slowly wrt cranium (negative
allometry)
Juvenile apes & humans resemble
each
other
=>
Relatively
enlarged
cranium
of
Homo is a retained juvenile
trait
Acceleration can be produced by
acceleration
of somatic growth wrt size
In many species,
pattern
formation is dependant on cytodifferentiation:
where & when do mitoses occur?
Ex.: In floral
bud formation, petal primordia are separated by intercalary
cells
If
mitoses
in
intercalary
cells
are slow lobate
flowers
fast
sympetalous
floral tubes
Floral
morphology
will
determine
pollinator
type:
bees
on
lobate
flowers
versus hummingbirds on sympetalous
floral
tubes.
Ex.:
Digit
formation in vertebrates
Distinct digits are the result of programmed cell death (apoptosis)
of intercallary cells
Terrestrial species have accelerated rate wrt aquatic species
e.g.,
chicken
versus duck feet
Can
systemic mutations produce "Hopeful
Monsters"? (Goldschmidt 1940)
Single mutations affect
entire developmental systems
dachshund
(German:
"badger
dog")
is
an
achondroplastic
beagle
Similar
mutations
are
found
in
cattle & Ancon sheep
mutation is preserved because dachshund "fills a niche"
Modification of leg
& ankle bones in Gallus
Hampé
experiment restored 250 MY-old pattern
Homeotic
mutations
in Drosophila
Cuticular structures
(legs, wings, antennae, etc.) are formed from imaginal disks
Imaginal disks are paired, undifferentiated structures in larvae
Metamorphosis of disks is under local hormonal control
Homeotic mutants
cause transdetermination of
imaginal
disk fates
antennapedia:
antenna disks transdetermined to legs
bithorax:
posterior
segment
of
thorax
transdetermined
to anterior segment
Dipteran (Di
+ ptera = two-wing)
flies grow two pairs
of wings (halteres
wings)
[Could
this
be
the
origin
of Diptera
from "tetraptera" ancestors?]
All text material © 2010 by Steven M. Carr