Notions in Antiquity
Aristotle:
Male Form
imposed on Female Substance:
cf. sculptor on clay
Left versus right testis (experimental?)
Plato’s
Symposium:
Drinking party
proposes origins as three pairs of conjoined twins
FF / MF / MM -> lesbian, hetero,
gay
Galen
(ca 200 CE): 3 ♂ + 3 ♀ uterine
locations determine sex of offspring
T
Aquinas (~1250) contrasts male
versus female anatomy
W
Harvey (1578 – 1657): uterine
scars in post-partum animals
A Vesalius / L da Vinci:
gross anatomy
of anatomical differences
Modern
Period
Eggs come from Ovary
R
de Graaf (1641 – 1673): ovarian follicles
Assumed follicle
= ovum
KE
von Baer (1792 – 1876): human ovum (1827)
Schwann:
mammalian ovum as single cell (1834)
G
Falloppio (1523 – 1262): oviduct conducts ovum ->
uterus
T
Bischoff (1807 - 1882): ovum in rabbit follicle (1842)
Sperm as agents of reproduction
A Leeuwenhoek (1688) sees human sperm:
(non-reproductive) ‘animalcules’
?
O
Bütschli (1848 - 1920): mitosis in
nematodes (1873)
E
van Beneden (1846 - 1910): meiosis and pronuclei in Ascaris (2N =
4)
Fertilization
L Spallanzani
(1729 - 1799): artificial fertilization of
frog egg w/ added sperm (1784)
artificial insemination of dog (1780s)
O
Hertwig (1849 - 1922): pronuclear fusion of
sperm & egg in sea urchins (1876)
Cytology anticipates Mendelism
A
Weismann (1834 - 1914): reduction
division necessary in germ line theory (1880s)
H
Henking (1858 – 1942): “X element”
in male
C
McClung (1870 – 1946): unpaired “X” in male grasshoppers
only (1898)
T
Montgomery (1873 – 1912): pairing of
chromosomes in meiosis
W Sutton
& T Boveri
propose chromosomes
follow Mendelian
Laws (~1903)
EB Wilson characterizes females w/ XX, males
w/ XY: anticipates TH Morgan
N
Stevens (1861 – 1912): hetero-chromosome
(later, Y) in
Tenebrio (1905)
Alternatives
XX
& XO
beetles (EB Wilson & students)
L Doncaster (1877 – 1920): ZW & ZZ birds reverse mammalian pattern
2N
& N
Hymenoptera ("queens" vs workers, drones): haplo-diploid sex determination
Dosage
compensation (HJ
Muller 1932)
MF
Lyon (1925 – 2014): heterochromatization
(“Lyonization”)
of alternate Xs
Alternative (correct) explanation of tortoiseshell / calico cats
Hormonal mechanisms in sex
determination
F
Lillie (1870 – 1947): origin of freemartin
cattle (1916)
Fraternal twin ♂ /♀
cattle w/ anastomosed chorions:
male “masculinizes”
female
cf. 70% of women in Huxley’s “Brave
New World” (1931)
Testosterone
isolated, synthesized
(1934); restores virility to castrated birds, mammals
Follicle Stimulating Hormone (FSH) induces egg production
Luteinizing Hormone (LH) induces
formation of corpus
luteum
Anti-Mullerian Hormone (AMH) suppresses
female structures
Non-standard
combinations of cytology & hormonal environments
“Hermaphrodites”
(both genitalia)
vs “Pseudo-hermaphrodites”
(contrasted internal & external genitalia)
Non-disjunction: XO (Turner
Syndrome: 1938) XY XO
mosaic Turner
Fusion: XX
+ XY at blastocyst stage “true”
hermaphrodites
SRY
gene at Yp11.2
XY
includes SRY [Sex-Regulating Y] locus
standard
male
XY does
not include SRY
AIS (Androgen-Insensitivity
Syndrome)
Formerly
known as TFS (Testicular Feminization Syndrome)
External female genitalia & 2o
appearance: absent / streak gonads
XX with
SRY insertion
external
male genitalia; sterile
Contrast genetic, anatomy, & orientation
sex & sexuality
In sport:
the 1968 Olympics & subsequently
Learned vs Innate
Genetic vs non-genetic innate
Evolutionary psychology
Implications of Sex
Darwinian Sexual Selection
Secondary Sex
characteristics (antlers, peacock tails,
bright colors in (male) birds)
Deleterious as survival traits:
e.g., more conspicuous to predators
Advantageous as reproductive
trait: > Survival value
Genetic Recombination
Asexual clones more successful
in short-term, constant environment
Sexual species more successful
in long-term, variable environments