Ross Feldman

Professor, Chair of Medicine MD, FACP, FAHA, FRCPC




What brought me to MUN? What keeps me at MUN?

I came to Memorial for the opportunity, the people and the adventure. I wanted to be a part of an organization and a Discipline that was growing and developing. I am grateful to be able to have a role to help foster that development. Beyond that the opportunity to be able to have the culture, music and dramatic land and sea scapes of Newfoundland and Labrador at my doorstep is a great fringe benefit!


Education:

M.D. Queen’s University


Training:

Internal Medicine, University of Toronto
Clinical Pharmacology, Vanderbilt University


Research/Teaching Summary:

My clinical research focuses on the management of hypertension and specifically the development of innovative strategies to improve blood pressure control. My major fundamental research program focused on the elucidation of novel cell signaling mechanisms of vascular regulation/dysregulation linked to the development of hypertension and atherosclerosis. The laboratory has uncovered important mechanisms which may explain the basis for some of the benefits (and risks) of hormone replacement and more generally the effects on cardiovascular function/development of heart disease of estrogen and other related hormones like aldosterone.
Among a range of editorial responsibilities, I am currently an Associate Editor for both the Canadian Journal of Cardiology and for the Canadian Journal of Physiology and Pharmacology. I am also a member of the editorial board of the American Journal of Physiology-Cell Physiology. He is the immediate past editor of Pharmacological Reviews.
I have taken leadership roles in a number of scientific and professional organizations in the disciplines of medicine and pharmacology. I have been Vice-President of the American Society of Clinical Pharmacology and Therapeutics and Chair of the Clinical Pharmacology Division of the American Society of Pharmacology and Experimental Therapeutics. I have served as Chair of the Scientific Review Committee of the Heart and Stroke Foundation of Canada and chair of the Research Committee of the Heart and Stroke Foundation of Ontario and as a member of the Board of Directors of the HSFO. I am the past Governor of the Ontario Chapter, American College of Physicians.
A major focus of my efforts has been in the prevention and control of hypertension in Canada and specifically in the knowledge translation of optimal treatment approaches for hypertension management. Among past leadership positions, I served as the first Chair of the Steering Committee of the Canadian Hypertension Education Program. As well, I served as President of the Canadian Hypertension Society. I was also the founding President of Hypertension Canada- leading the process of integrating the efforts of the Canadian Hypertension Society, Canadian Hypertension Education Program and Blood Pressure Canada into what is now the second largest cardiovascular disease not-for-profit agency in Canada .

Awards:

I have received a number of awards and scholarships in recognition of contributions in research, teaching and for my efforts in the prevention and control of hypertension in Canada. These include the George Morris Piersol Research and Teaching Scholarship from the American College of Physicians, a Career Investigator Award from the Heart and Stroke Foundation of Ontario, the Burroughs-Wellcome Clinical Pharmacology Award and the Senior Investigator Award from the Canadian Society for Clinical Pharmacology as well as the Distinguished Service/Research Award of the Canadian Hypertension Society. In 2010 I received the George Fodor Award from Hypertension Canada for outstanding contributions to the prevention and control of hypertension.



Publications: (from 2013)

Gros R, Ding Q, Liu B, Chorazyczewski J, Feldman RD Aldosterone mediates its rapid effects in vascular endothelial cells through GPER/GPR30 activation. Am J Physiol Cell Physiol 2013 Mar;304(6):C532-540.

Campbell NR, Feldman RD, Kaczorowski J, Larochelle, P. High blood pressure selected as the theme for World Health Day April 7 2013: Cup half full or half empty? Can J Cardiol 2013 Apr;29(4):415-417.

Hackam DG, Quinn RR, Ravani P, Rabi DM, Dasgupta K, Daskalopoulou SS, Khan NA, Herman RJ, Bacon SL, Cloutier L, Dawes M, Rabkin SW, Gilbert RE, Ruzicka M, McKay DW, Campbell TS, Grover S, Honos G, Schiffrin EL, Bolli P, Wilson TW, Feldman RD, Lindsay P, Hill MD, Gelfer M, Burns KD, Vallée M, Prasad GV, Lebel M, McLean D, Arnold JM, Moe GW, Howlett JG, Boulanger JM, Larochelle P, Leiter LA, Jones C, Ogilvie RI, Woo V, Kaczorowski J, Trudeau L, Petrella RJ, Milot A, Stone JA, Drouin D, Lavoie KL, Lamarre-Cliche M, Godwin M, Tremblay G, Hamet P, Fodor G, Carruthers SG, Pylypchuk GB, Burgess E, Lewanczuk R, Dresser GK, Penner SB, Hegele RA, McFarlane PA, Sharma M, Reid DJ, Tobe SW, Poirier L, Padwal RS; Canadian Hypertension Education Program. The 2013 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension. Can J Cardiol 2013 May;29(5):528-542.

Feldman RD, Brass EP. From bad behavior to bad biology: pitfalls and promises in the management of resistant hypertension. Can J Cardiol 2013 May;29(5):549-556.

Dresser GK, Nelson SA, Mahon JL, Zou G, Vandervoort MK, Wong CJ, Feagan BG,
Feldman RD. Simplified therapeutic intervention to control hypertension and hypercholesterolemia: a cluster randomized controlled trial (STITCH2). J Hypertens 2013 Aug;31(8):1702-1713.

Sadri H, Pietzsch JB, Geisler BP, Padwal R, Vallée M, Feldman RD. Cost-effectiveness of catheter-based renal denervation for resistant hypertension–a Canadian perspective. Value in Health 2013 16(3):A284-A285.

Feldman RD, Gros R. Vascular effects of aldosterone: sorting out the receptors and the ligands. Clin Exp Pharmcol Physiol 2013: 2013 Dec;40(12):916-921.

Nolan RP, Liu S, Feldman R, Dawes M, Barr S, Lynn H, Gwardy-Sridhar F, Thomas SG, Goodman J, Oh P, Kaczorowski J, Chessex C, Hachinski V, Shoemaker K. Reducing risk with e-based support for adherence to lifestyle change in hypertension (REACH): protocol for a multicentred randomised controlled trial. BMJ open 2013 3(8):e003547.

Feldman RD. Aldosterone and blood pressure regulation: recent milestones on the long and winding road from electrocortin to KCNJ5, GPER, and beyond. Hypertens 2014 Jan;63(1):19-21.

Khan NA, Herman RJ, Quinn RR, Rabkin SW, Ravani P, Tobe SW, Feldman RD, et al. Renal denervation therapy for the treatment of resistant hypertension: a position statement by the Canadian Hypertension Education Program. Can J Cardiol 2014 Jan;30(1):16-21.

Ferguson SSG, Feldman RD. Beta adrenoceptors as molecular targets in the treatment of hypertension. Can J Cardiol 2014 May;30(5 Suppl):S3-8.

Dasgupta K, Quinn RR, Zarnke KB, Rabi DM, Ravani P, Daskalopoulou SS, Rabkin SW, Trudeau L, Feldman RD, Cloutier L, Prebtani A, Herman RJ, Bacon SL, Gilbert RE, Ruzicka M, McKay DM, Campbell TS, Grover S, Honos G, Schiffrin EL, Bolli P, Wilson TW, Lindsay P, Hill MD, Coutts SB, Gubitz G, Gelfer M, Vallée M, Prasad GV, Lebel M, McLean D, Arnold JM, Moe GW, Howlett JG, Boulanger JM, Larochelle P, Leiter LA, Jones C, Ogilvie RI, Woo V, Kaczorowski J, Burns KD, Petrella RJ, Hiremath S, Milot A, Stone JA, Drouin D, Lavoie KL, Lamarre-Cliché M, Tremblay G, Hamet P, Fodor G, Carruthers SG, Pylypchuk GB, Burgess E, Lewanczuk R, Dresser GK, Penner SB, Hegele RA, McFarlane PA, Khara M, Pipe A, Oh P, Selby P, Sharma M, Reid D, Tobe SW, Padwal RS, Poirier L. The 2014 Canadian Hypertension Education Program (CHEP) Recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention and treatment of hypertension. Can J Cardiol 2014 May;30(5):485-501.

Feldman RD, Nattel S. Increasing appreciation for the role of single pill combinations for the prevention of atherosclerotic disease: a pro-polypill polemic. Can J Cardiol 2014 May;30(5):517-519.

Rash JA, Lavoie KL, Feldman RD, Campbell TS. Adherence to antihypertensive medications: current status and future directions. Curr Cardiovasc Risk Rep 2014 8(12):1-13.

Feldman RD, Gros R, Ding Q, Hussain Y, Ban MR, McIntyre AD, Hegele RA. A common hypofunctional genetic variant of GPER is associated with increased blood pressure in women. Br J Clin Pharmacol 2014 Dec;78(6):1441-1452.

Ding Q, Hussain Y, Chorazyczewski J, Gros R, Feldman RD. GPER-independent effects of estrogen in rat aortic vascular endothelial cells. Mol Cell Endocrinol 2015 Jan;399:60-68.

Lother A, Moser M, Bode C, Feldman RD, Hein L. Mineralocorticoids in heart and vasculature: new insights for old hormones. Ann Rev Pharmacol Toxicol 2015 Jan;55:289-312.

Feldman RD, Hussain Y, Kuyper LM, McAlister FA, Padwal RS, Tobe SW. Intra-class differences among antihypertensive drugs. Ann Rev Pharmacol Toxicol 2015 Jan;55:333-352.

Kjeldsen S, Feldman RD, Lisheng L, Mourad JJ, Chiang CE, Zhang W, Wu Z, Li W, Williams B. Updated national and international hypertension guidelines: a review of current recommendations. Drugs 2014 Nov;74 (17):2033-2051.

Hussain Y, Ding Q, Connelly PW, Brunt JH, Ban MR, McIntyre AD, Huff MW, Gros R, Hegele RA, Feldman RD. G-protein estrogen receptor as a regulator of low-density lipoprotein cholesterol metabolism: cellular and population genetic studies. Arterioscler Thromb Vasc Biol 2015 Jan; 35(1): 213-221.

Feldman RD, Anderson TJ, Touyz RM. Metabolic syndrome sinkholes: what to do when Occam’s razor gets blunted. Can J Cardiol 2015 May; 31:601-604.

Stella S Daskalopoulou, Doreen M Rabi, Kelly B Zarnke, Kaberi Dasgupta, Kara Nerenberg, Lyne Cloutier, Mark Gelfer, Maxime Lamarre-Cliche, Alain Milot, Peter Bolli, Donald W McKay, Guy Tremblay, Donna McLean, Sheldon W Tobe, Marcel Ruzicka, Kevin D Burns, Michel Vallée, GV Ramesh Prasad, Marcel Lebel, Ross D Feldman, Peter Selby, Andrew Pipe, Ernesto L Schiffrin, Philip A McFarlane, Paul Oh, Robert A Hegele, Milan Khara, Thomas W Wilson, S Brian Penner, Ellen Burgess, Robert J Herman, Simon L Bacon, Simon W Rabkin, Richard E Gilbert, Tavis S Campbell, Steven Grover, George Honos, Patrice Lindsay, Michael D Hill, Shelagh B Coutts, Gord Gubitz, Norman RC Campbell, Gordon W Moe, Jonathan G Howlett, Jean-Martin Boulanger, Ally Prebtani, Pierre Larochelle, Lawrence A Leiter, Charlotte Jones, Richard I Ogilvie, Vincent Woo, Janusz Kaczorowski, Luc Trudeau, Robert J Petrella, Swapnil Hiremath, James A Stone, Denis Drouin, Kim L Lavoie, Pavel Hamet, George Fodor, Jean C Grégoire, Anne Fournier, Richard Lewanczuk, George K Dresser, Mukul Sharma, Debra Reid, Geneviève Benoit, Janusz Feber, Kevin C Harris, Luc Poirier, Raj S Padwal, Canadian Hypertension Education Program. The 2015 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension. Can J Cardiol 2015 May; 31:549-568.

Campbell NRC, Feldman RD. Hypertension in Canada and the global context: the wine is vintage and the glass is two thirds full but is the bottle empty? Can J Cardiol 2015 (in press)

Feldman RD, Limbird LE. Copernicus revisited: Overturning Ptolemy’s view of the GPER universe. Trends in Endocrinology and Metabolism (in press)