R. Gill and M. O’Brien, A. Young, D. Gardiner, and Ryan J. Mailloux, Protein S-glutathionylation lowers superoxide/hydrogen peroxide release from skeletal muscle mitochondria through modification of complex I (2018), PLOS ONE, IN REVISION.

A. Young, M. O’Brien, R. Gill, Ryan J. Mailloux, Simultaneous measurement of superoxide/hydrogen peroxide and NADH production by flavin-containing mitochondrial dehydrogenases (2018), Journal of Visualized Experiments, ACCEPTED, JoVE56975R2

J. Chalker, D. Gardiner, N. Kuksal, Ryan J. Mailloux, Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria (2018), Redox Biology, 15:216-227

N. Kuksal, J. Chalker, and Ryan J. Mailloux (2017), Progress in understanding the molecular oxygen pa-redox; function of mitochondrial reactive oxygen species in cell signaling, Biological Chemistry (2017), 398(11):1209-1227

A. Young, D. Gardiner, M.E. Brosnan, J.T. Brosnan, Ryan J. Mailloux, Physiological levels of formate activate mitochondrial superoxide/hydrogen peroxide release from mouse liver mitochondria, FEBS Letters (2017), 591(16):2426-2438.

L. Slade, J. Chalker, N. Kuksal, A. Young, D. Gardiner, and Ryan J. Mailloux, Examination of the superoxide/hydrogen peroxide forming and quenching potential of mouse liver mitochondria, BBA General Subjects (2017), 1861(8):1960-1969.

M. O’Brien and J. Chalker, L. Slade, Gardiner D. and Ryan J. Mailloux (2017), S-glutathionylation modulates superoxide/hydrogen peroxide emission from pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase in liver mitochondria, Free Radical Biology and Medicine, 106:302-314.

Ryan J. Mailloux, A. Young, J. Chalker, D. Gardiner, M. O’Brien, and J.T. Brosnan, Production of mitochondrial superoxide/hydrogen peroxide by one-carbon donating metabolites, choline and dimethylglycine (2016), FEBS Letters, 590(23):4318-4328.

Ryan J. Mailloux, D. Gardiner, M. O’Brien, Comparison of O2?-/H2O2 production by Krebs cycle enzymes pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase (2016), Free Radical Biology and Medicine, 97:501-12.

Ryan J. Mailloux, Application of mitochondria-targeted pharmaceuticals to the treatment of heart disease (2016) Current Pharmaceutical Design, 22(31):4763-4779

S. Robitaille, Ryan J. Mailloux, L. Chan, Methylmercury alters glutathione homeostasis in human astrocytoma cell line CCF-STTG1 (2016), Toxicology Letters, 256:1-10

L. Mahemuti, Q. Chen, M. C. Coughlan, M. Zhang, M/ Florian, Ryan J. Mailloux, X.L. Cao, K. A. Scoggan, W. G. Willmore, X. Jin, Journal of Environmental Sciences (2016), 48:11-23

Ryan J. Mailloux, Craig Ayre, Sherri Christian, Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase (2016), Redox Biology, 17;8:285-297

Ryan J. Mailloux, Treberg JR, Protein S-glutathionylation links energy metabolism to redox signaling in mitochondria (2016), Redox Biology, 8:110-118

Y. Shao, D. Figeys, Z. Ning, Ryan J. Mailloux, L. Chan, Effects of Methylmercury on MN9D dopaminergic neuron cells: a genomic and proteomic analysis (2015), J Toxicol Sci.;40(6):817-28

Ryan J. Mailloux, E. Yumvihoze, L. Chan, O2?- produced in the matrix of mitochondria enhances methylmercury toxicity in human neuroblastoma cells (2015), Toxicol Appl Pharmacol. pii: S0041-008X(15)30128-9

Ryan J. Mailloux, E. Yumvihoze, L. Chan, Superoxide anion radical (O2-?) degrades methylmercury to inorganic mercury in human astrocytoma cells (2015), Chemico-Biological Interactions, 239:46-55

Ryan J. Mailloux, Still at the center of it all; novel functions of the oxidative Krebs cycle, Bioenergetics 2015, 4:1

A. Fu*, Ryan J. Mailloux*, M. Florian, W., D. Jin Northern contaminants reduce serum insulin levels due to pancreatic beta cell loss (2015), Toxicology, Jun 9;334:81-93.

J. Truong, Ryan J. Mailloux, L. Chan, Impact of methylmercury exposure on mitochondrial energetics in AC16 and H9C2 cardiomyocytes (2015), Toxicology In Vitro 29(5):953-61

Ryan J. Mailoux, Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species (2015), Redox Biology, 4:381-98.

Ryan J. Mailloux and W.G. Willmore, S-glutathionylation reactions in mitochondrial metabolism and disease (2014), Frontiers in Cellular and Developmental Biology, 2: 68

D. A. Patten, M. Germain, J. Wong, M. Khacho, V. Soubannier, Ryan J Mailloux, K. Pilon-Larose, J. G. MacLaurin, D.S. Park, H. M. McBride, L. Trinkle-Mulcahy, M. Harper, R. Slack, OPA1 senses metabolic changes through SLC25 family proteins to regulate mitochondrial function (2014), EMBO Journal, 33(22):2676-91

Ryan J. Mailloux, M. Florian, Q. Chen, Y. Jin, I. Petrov, M. Coughlan, M. Laziyan, D. Caldwell, M. Lalonde, D. Patry, C. Gagnon, K. Saraffin, N. Ratnayake, N. Li, W.G. Willmore, X. Jin, Exposure to a Northern Contaminant Mixture (NCM) compromises hepatic energy metabolism and exacerbates non-alcoholic fatty liver disease in obese JCR rats (2014), PLOS ONE 9(9):e106832.

Ryan J. Mailloux, J. Xuan, S. Mcbride, W. Maharsy, S. Thorn, C. Holterman, C. R.J. Kennedy, P. Rippstein, R. deKemp, J. da Silva, M. Nemer, M. Lou, and ME Harper, Grx2-mediated glutathionylation reactions control oxidative phosphorylation in cardiac tissue (2014), Journal of Biological Chemistry, 289 (21):14812-28

Naif Almontashiri, Hsiao-Huei Chen, Ryan Mailloux, Takashi Tatsuta, Allen Teng, Ahmad Mahmoud, Tiffany Ho, Nicolas Stewart, Peter Rippstein, Mary-Ellen Harper, Robert Roberts, Jeanette Erdmann, Annalisa Pastore, Heidi McBride, Thomas Langer, Alex Stewart, Mitochondrial protease SPG7 variant increases mitochondrial ROS production and coronary artery disease risk (2014), Cell Reports, 7(3):834-47

J. Lemire, C. Auger, R. Mailloux, VD Appanna. Mitochondrial lactate metabolism is involved in antioxidative defense in human astrocytoma cells (2014) J Neurosci Res. 92(4):464-75

R. Mailloux, X. Jin, W.G. Willmore, Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions, (2014) Redox Biology, 2:123-139 Rated one of the most highly cited articles at Redox Biology (over 100 citations)

R. Mailloux, S. McBride, and ME Harper, Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics (2013), Trends in Biochemical Sciences, 38(12):592-602

C. Adjeitey, R. Mailloux, R. deKemp, and ME Harper, Mitochondrial uncoupling in skeletal muscle through UCP1 augments energy expenditure and glutathione content, while mitigating ROS production (2013), American Journal of Physiology; Endocrinology and Metabolism, 305(3):E405-15.

R. Mailloux, J. Xuan, B. Beauchamp, L. Jui, M. Lou, and ME. Harper, Glutaredoxin-2 is required to control proton leak through uncoupling protein-3 (2013), Journal of Biological Chemistry, 288, 8365–8379

A. Pfefferle, R. Mailloux, and ME. Harper, Glutathionylation of UCP2 sensitizes drug resistant cancer cells to chemotherapeutics (2013), BBA Molecular Cell Research 1833(1):80-89

R. Mailloux, A. Fu, C. Robson-Doucette, E. Allister, MB. Wheeler, R. Screaton, and ME. Harper, Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion (2012), Journal of Biological Chemistry, 287(47):39673-85.

R. Mailloux and ME. Harper, Mitochondrial bioenergetics and control of ROS signaling. Trends in Endocrinology and Metabolism (2012), 23(9):451-8.

R. Mailloux, C. Adjeitey, J. Xuan, and ME. Harper. Crucial yet divergent roles of mitochondrial redox state in skeletal muscle versus brown adipose tissue energetics. FASEB Journal (2012), 26(1):363-75.

C. Aguer, D. Gamborotta, R. Mailloux, C. Moffat, R. McPherson, R. Dent, and ME Harper. Galactose Enhances Oxidative Metabolism and Reveals Mitochondrial Dysfunction in Human Primary Muscle Cells. PLoS ONE (2011), 6(12): e28536.

R. Mailloux, J. Lemire, and V. Appanna. Hepatic response to aluminum toxicity: Dyslipidemia and liver diseases. Experimental Cell Research (2011). 317(16):2231-8.

R. Mailloux and ME. Harper. Uncoupling proteins and the control of cellular reactive oxygen species production. Free Radical Biology and Medicine (2011). 51(6):1106-15. Rated one of the most highly cited articles at Free Radical Biology and Medicine since 2011 (over 280 citations)

R. Mailloux, E. Seifert, F. Bouillaud, C. Aguer, S. Collins, and ME. Harper. Glutathionylation ; the control switch for uncoupling protein 2 and 3. Journal of Biological Chemistry (2011). 286(24):21865-75.

R. Mailloux, C. Aguer, T. Dumouchel, R. de Kemp, R. Beanlands, and ME. Harper. Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration. Biochemical Journal (2011). 437: 301-311.

J. Lemire, R. Mailloux, R. Darwich, and V. Appanna. The disruption of L-carnitine metabolism by aluminum toxicity and oxidative stress promotes dyslipidemia in human astrocytic and hepatic cells. Toxicology Letters (2011). 203(3):219-26.

R. Mailloux, J. Lemire, and V. Appanna. Metabolic networks to combat oxidative stress in Pseudomonas fluorescens. Antonie van Leeuwenhoek (2011). 99(3):433-42.

R. Mailloux, C. Adjeitey, and ME Harper. Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents. PLoS ONE (2010). 5(10). e13289.

J. Lemire, R. Mailloux, C. Auger, and V. Appanna. Pseudomonas fluorescens orchestrates a fine metabolic-balancing act to counter aluminum toxicity (2010). Environmental Microbiology and Environmental Microbiology Reports. 12(6): 1384-1390.

R. Mailloux and M.E. Harper. Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase (2010). FASEB Journal. 24(7): 2495-2506

R. Singh, J. Lemire, R. Mailloux, Daniel Chenier, Robert Hamel, and V. Appanna (2009). An ATP and Oxalate Generating Variant Tricarboxylic Acid Cycle Counters Aluminum Toxicity in Pseudomonas fluorescens. PLoS ONE. 4(10): e7344.

R. Mailloux, R. Singh, G. Brewer, C. Auger, J. Lemire, V. Appanna (2009) Alpha-ketoglutarate dehydrogenase and glutamate dehydrogenase work in tandem to modulate the antioxidant alpha-ketoglutarate during oxidative stress in Pseudomonas fluorescens. Journal of Bacteriology. 191(12):3804-10

J. Lemire, R. Mailloux, S. Puiseux-Dao, and V. Appanna (2009) Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells. Journal of Neuroscience Research. May 1;87(6):1474-83

R. Mailloux, S. Puiseux-Dao, and V. Appanna (2009) α-Ketoglutarate abrogates the nuclear localization of HIF-1α in aluminum-exposed hepatocytes. Biochimie. Mar;91(3):408-15

R. Singh, J. Lemire, R. Mailloux, and V. Appanna (2008) A novel strategy involved in anti-oxidative defense: the conversion of NADH into NADPH by a metabolic network. PLoS ONE. 16;3(7):e2682.

J. Lemire, R. Mailloux and V. Appanna (2008) Mitochondrial lactate dehydrogenase is involved in oxidative-energy metabolism in human astrocytoma cells (CCF-STTGI). PLoS ONE 3(2): e1550.

R. Mailloux, R. Darwich, J. Lemire and V. Appanna (2008) The monitoring of nucleotide diphosphate kinase activity by blue native polyacrylamide electrophoresis. Electrophoresis. 29(7):1484-9.

J. Lemire, R. Mailloux and V. Appanna (2008) Zinc toxicity alters mitochondrial metabolism and leads to decreased ATP production in hepatocytes. Journal of Applied Toxicology. 28(2):175-82.

J. Lemire, P. Kumar, R. Mailloux, K. Cossar and V. Appanna (2008) Metabolic adaptation and oxaloacetate homeostasis in Pseudomonas fluorescens exposed to aluminum toxicity. J. Basic Microbiology. Aug;48(4):252-9.

R. Mailloux, J. Lemire and V. Appanna (2008) A novel metabolic network leads to enhanced citrate biogenesis in Pseudomonas fluorescens exposed to aluminum toxicity. Extremophiles. 12(3):451-9.

D. Chénier, R. Bériault, R. Mailloux, M. Bacquie, G. Abramia, J. Lemire and V. Appanna (2008) Metabolic adaptation in Pseudomonas fluorescens evoked by aluminum and gallium toxicity: Involvement of fumarase C and NADH oxidase. Applied and Environmental Microbiology. 74(13): 3977-84

R. Bériault, R. Hamel, D. Chénier, R. Mailloux, H. Joly and V. Appanna (2007) The overexpression of NADPH-producing enzymes counters the oxidative stress evoked by gallium, an iron mimetic. Biometals 20: 165-176.

R. Mailloux, J. Lemire and V. Appanna (2007) Aluminum-induced mitochondrial dysfunction leads to lipid accumulation in hepatocytes: A possible link to obesity. Cellular Physiology and Biochemistry. 20: 627-638

R. Mailloux, R. Bériault, J. Lemire, D. Chénier, R. Singh, R. Hamel and V. Appanna (2007) The Tricarboxylic Acid Cycle, an Ancient Metabolic Network with a Novel Twist. PLoS ONE 2(8): e690.

R. Singh, R. Mailloux, S. Puiseux-Dao and V. Appanna (2007) Oxidative stress evokes a metabolic adaptation that favours increased NADPH synthesis and decreased NADH production in Pseudomonas fluorescens. Journal of Bacteriology. 189: 6665-6675.

R. Mailloux and V. Appanna (2006) Aluminum toxicity triggers the nuclear translocation of HIF-1α and promotes anaerobiosis in hepatocytes. Toxicology in Vitro. 21 : 16-24

R. Mailloux, R. Singh and V. Appanna (2006) In-gel activity staining of NAD+ kinase by Blue Native-PAGE. Analytical Biochemistry. 359 : 210-215

R. Singh, R. Bériault, D. Chénier, J. Middaugh, R. Mailloux, R. Hamel and V. Appanna (2006) Simultaneous monitoring numerous TCA cycle enzymes by Blue Native Polyacrylamide Gel Electrophoresis. Asian Journal of Biochemistry. 1 : 297-306

R. Mailloux, R. Hamel and V. Appanna (2006) Aluminum toxicity elicits a dysfunctional TCA cycle and succinate accumulation in hepatocytes. Journal of Biochemical and Molecular Toxicology. 20 : 198-208

R. Singh, D. Chénier, R. Bériault, R. Mailloux , R.D. Hamel and V. Appanna (2005) Blue Native Polyacrylamide Gel Electrophoresis and the Monitoring of Malate- and Oxaloacetate -Producing Enzymes. J. Biochem. and Bioph. Meth. 64: 189-199

R. Bériault, D. Chénier, R. Singh, J. Middaugh, R. Mailloux and V. Appanna (2005) Detection and purification of glucose 6-phosphate dehydrogenase, malic enzyme and NADP-dependent isocitrate dehydrogenase by blue native polyacrylamide gel electrophoresis. Electrophoresis 26, 2892–2897