The Journal was founded in 1957 as Échos du monde classique/Classical News and Views. Its object was to provide news, opinions, and articles of general and pedagogical interest to members of the Classical Association of Canada. From 1965 to 1981 the Journal was edited at the University of Ottawa by Colin M. Wells and (from 1974) Susan M. Treggiari. In that period the Journal took on the additional function of publishing reports of archaeological discoveries made by Canadian scholars. It also began to attract a wider scholarly audience, both in and outside Canada, and to develop a more research-oriented character, publishing substantial articles in all fields of classical scholarship (literature, history, archaeology).

From 1981 to 1984 the Journal was edited at the University of Calgary by Waldemar Heckel and John C. Yardley, with Martin Cropp as Associate Editor. In 1982 the Journal's format was altered from 8 x 11 inch typescript and staple-bound to 5 1/2 x 8 1/2 inch perfect-bound and its name changed to Échos du monde classique/Classical Views. James Russell of the University of British Columbia became editor in charge of the annual archaeological issue, and for the first time the Journal appointed editorial correspondents. From 1984 to 1990 John Yardley and Martin Cropp served as Joint Editors and, in 1987, further modified the format to 6 x 9 inch copy; financial assistance from the University of Calgary and the Social Sciences and Humanities Research Council of Canada facilitated technical improvements in the Journal. Circulation of EMC/CV increased dramatically, especially to university libraries, while its international scholarly reputation began to grow.

In 1990 the editorship of the Journal passed to the University of Victoria. The Victoria editors (Keith Bradley, John Oleson, and Sam Scully) continued to raise the international reputation of the Journal, attracting contributions from outside the country while retaining and consolidating the Journal's original and unique role of speaking to and for a broad range of classicists within Canada.

In 1994 the editorship of the Journal passed to James Butrica and Mark Joyal at Memorial University, where several further improvements in format were made, such as the inclusion of French abstracts of English articles and English abstracts of French articles, the appearance of plates and illustrations within the body of an article, and the adoption of a characteristically French style of formatting for articles in French. In 2003, Lea Stirling came on as editor of the Archaeological issue.

In 1997 the constitution of the Classical Association of Canada was changed to recognize Échos du monde classique/Classical Views officially as one of the Association's two journals. In 2001 the title of the Journal was changed to Mouseion: Journal of the Classical Association of Canada/Revue de la Société canadienne des études classiques.

A new editorial team, consisting of John Geyssen of the University of New Brunswick as Editor, together with Myles McCallum of Saint Mary's University and Hans vanderLeest of Mount Allison University as Archaeological Editors, took over in 2008. In 2010, they were joined by Kathryn Simonsen of Memorial University as Book Review Editor.

In 2011, upon the untimely passing of John Geyssen, Brad Levett of Memorial University became Editor for the existing editorial board. In addition, Guy Chamberland of Thorneloe University joined as editor of French language submissions and Craig Maynes of Memorial University as Secretary-Treasurer.