When p53 detects irreparable damageto the
cell it induces apoptosis
How does p53 induce apoptosis?
3 Possible Ways:
1. Binds to Bax protein p53 binding site = cytochrome c released from mitocondria
2. p53-induced genes (PIGs) activate an increase in reactive oxygen species (ROS) = damage to the mitochondria
3. Over expression of Fas, that is p53 dependent = caspase activation
How does p53 induce apoptosis?
3 Possible Ways:
1. Binds to Bax protein p53 binding site = cytochrome c released from mitocondria
2. p53-induced genes (PIGs) activate an increase in reactive oxygen species (ROS) = damage to the mitochondria
3. Over expression of Fas, that is p53 dependent = caspase activation