Cri-du-Chat
Syndrome
Cri-du-Chat
syndrome is the result of a segmental
aneuploid deletion of a portion of the short arm (2n=46,5p-) of Chromosome 5 [see
karyotype]. Symptoms include a characteristic
high-pitched cry ("cat
cry"), low birth weight, poor muscle tone,
microcephaly, and developmental retardation. Children
respond well to the home environment, and
institutionalization is now less common.