c04fig007.jpgHeterozygote Advantage

Change in frequency of A1 in the case of heterozygote advantage
W11 = 0.2, W12 = 1.0, W22 = 0.4

    Heterozygote advantage occurs when the fitness of the heterozygous genotype is superior to that of either homozygote. [This is often called "Overdominance," which is misleading because genotypes do not "dominate" other genotypes]. For the initial values of f(A1) = 0.001, 0.1, 0.9, 0.999, as shown, p will converge rapidly on an equilibrium value (: read "p hat") where p = 0.0. The equilibrium is calculated as = (1 - W22) / (2 - [W11 + W22]), provided the fitness of the heterozygote has been normalized as W12 = 1.0. In this case, = (1.0 - 0.4) / (2 - (0.2 + 0.4)) = (0.6 / 1.4) = 3 / 7 = 0.428571428571 = 0.43 as shown.

    In terms of selection coefficients s1 and s2 against the A1A1 and A2A2 genotypes, respectively, = s2 / (s1 + s2), again provided the fitness of the heterozygote has been normalized to 1. In this case, s1 = (1 - W11) = (1.0 - 0.2) = 0.8  and s2 = (1 - W22) = (1.0 - 0.4) = 0.6. Then s2 / (s1 + s2) = (0.6) / (0.8 + 0.6) =  3 / 7 = 0.43 as before.

    In both cases, note that the numerator for calculation of of the A1 allele involves the fitness expression for the alternative A2 allele. The more typical calculation of thus uses the expression for the A1 allele.

    The example shows the behavior of f(A1) = q under changing selection. At t = 0, A1 is under directional selection and decreases to q = 0.05 after 20 generations. At t = 20, the selection environment shifts to that shown above, and q = 0.43 as predicted after about 10 generations. Return to directional selection at t = 40 decreases q to the initial value at about t = 55, and the decrease continues thereafter, with the same slope.


Figure © 2019 Sætre & Ravinet; Text material © 2024 by Steven M. Carr