The pedigree is
typical for an X-linked recessive trait. The parents in the first generation
both have
standard vision; the mother
(circle) is heterozygous
with two
alleles,
n and
p.
Four combinations of gender and colour-deficiency are possible in their
children, and are expected with equal frequency:
carrier (heterozygous)
daughters with standard vision, standard daughters, standard sons, and
affected sons.
If the first-born daughter is a carrier and marries
a colour-deficient husband, they in turn can expect four types of
offspring at equal frequencies: carrier daughters, standard sons,
affected daughters, and affected sons. In the family on the far
right, the last-born
colour-deficient son marries a woman with standard vision, and only two
types of children can result: standard sons and carrier daughters.
Note that, in this family unlike the previous, colour-deficiency will
"skip" a generation, and may appear in the next generation in the sons
of the carrier daughters.
Note that the birth of an
affected woman requires an unusual combination of circumstances. Only
about 10% of men are affected, only about 18% of women are
carriers, thus only 1.8% of marriages are at risk, and only half of
their daughters will be a
homozygous recessive: 0.10 x 0.18 x 0.5 = 0.9% of daughters will be so
affected.
[
For the advanced student: if
f(p) = 0.1, then f(n) = 1 - 0.1, and f(np) = (2)(0.1)(0.9) = 0.18, and
(0.5 )(0.18) =0.09]