Recessive epistasis in the
diploid Arginine biosynthesis pathway: dihybrid crosses
Beadle
& Tatum analyzed the genetics of Arginine
biosynthesis in the haploid bread mold Neurospora.
The same pathway occurs in diploid organisms:
genetic analysis of mutant alleles affecting metabolic
intermediates of Arginine production provides a
general model for the behavior of multiple gene loci in
a single pathway.
Homework: The Punnet squares show the enzymatic [colour] and growth [+ or -] phenotypes of two crosses between two dihybrid auxotrophic mutants Assume dominance of the wild-type allele at each locus (x+). What general principles can be drawn from the patterns, as related to tri-hybrid crosses, and other forms of gene interactions in metabolic pathways?
Homework: The Punnet squares show the enzymatic [colour] and growth [+ or -] phenotypes of two crosses between two dihybrid auxotrophic mutants Assume dominance of the wild-type allele at each locus (x+). What general principles can be drawn from the patterns, as related to tri-hybrid crosses, and other forms of gene interactions in metabolic pathways?