Drift & Selection on rare alleles with weak selective
dis-advantage in finite populations
(N =
100, f(B0) = 0.005; W0 = W1
= 1.00, W2 = 0.99)
Trajectories of a weakly deleterious (s =
0.01) rare mutant allele in multiple populations (N
= 100 @) from an initial single copy f(B)
= 1/200 = 0.005. Most replicates go to f(B) =
0 within 25
generations: six remain polymorphic at t = 100
generations, three at t = 200, and only one at t
= 300 generations. One population has gone to
fixation, f(B) = 1.0, just short of t
= 200 generations, despite its selective disadvantage. Note
that s < 1/2N.
Figure &
Text material © 2024 by Steven
M. Carr