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Single- versus Multi-locus genetic trait distributions

    [Left] A quantitative trait determined by a single locus with two alternative alleles (A and B) occurs in three (31) genotypic classes (AA, AB, and BB), which correspond to three distinct phenotypes, if A is co-dominant with B. [Middle] As the number of contributing loci increases, e.g., from five loci (A1 A5) with 35 = 243 possible phenotype classes, or [Right] n loci with  3n classes,  the character distribution becomes essentially continuous, and follows the normal distribution.

    A multi-locus genetic model will satisfy the requirements for a normal distribution, if there are (1) many factors that (2) contribute independently to the feature, with (3) equal effect.



Figure ©2002 by Griffiths et al.; all text material ©2024 by Steven M. Carr