Deducing a gene map from
recombination data
The position of locus A on a chromosome is
known, the positions of loci B and C are
unknown. Dihybrid crosses establish that the
pairwise recombination distance between loci A & B and A & C are 5 cM and 3 cM, respectively. Two
possibilities then exist for the position of of locus C:
either it is between A and B, or
it is outside A on the opposite side
from B.
A third dihybrid cross is done with loci B
and C. The observed recombination distance of 2
cM establishes that locus C is between A
and B. Were it outside the A-B region, the
expected recombination distance between B and C
would be 8 cM, which is inconsistent with the
data.
[ Given the initial data, can C
be on the outside of B from A
? Explain. If it were, what would the
expected recombination distance between A & C
? ].