The
Central Dogma in
eukaryotic cells
In eukaryotes (organisms
with a
nuclear membrane),
DNA undergoes replication
and transcription
in the nucleus, and
proteins are made in the cytoplasm. RNA
must
therefore
travel across the nuclear membrane before it undergoes
translation. This
means that transcription
and translation are physically separated. The primary
transcript, heterogeneous
nuclear RNA
(hnRNA),
undergoes extensive post-transcriptional
processing to make a messenger RNA
(mRNA) molecule that can
pass through the nuclear membrane.
Figure
after
© 1996 by Griffiths et al. ; text © 2014 by
Steven M. Carr