Spontaneous & Gametic Mutation Rates
Bacterial
mutation rates are readily measured at the colony level:
reversion of
auxotrophic strains that require a particular amino
acid to
autotrophy can be measured as colony counts on
non-supplemented media.
The table includes gametic mutation rates for three
relatively common human DNA-based conditions; the
first two behave as dominant traits, for which rates are more
readily measured. Rates vary among populations, which may be
attributed to differences in efficiency of DNA repair
mechanisms. Non-inherited somatic mutation rates (e.g.,
for various form of cancer) are higher.