Single-nucleotide polymorphisms (SNPs) arise from "point mutations"
Sequence variation in a portion of the mtDNA cytochrome b genes from three species of North American deer

Mule    5'-ttc ggc tct ctg cta gga att tgc tta atc cta caa aat ctt act-3'
Deer        F   G   S   L   L   G   I   C   L   I   L   Q   N   L   T

Caribou 5'-ttt ggc tct cta cta gga atc tgc tta att cta caa atc ctt acc-3'
            F   G   S   L   L   G   I   C   L   I   L   Q   I   L   T

Moose   5'-ttc ggt tct cta tta gga gtt tgc tta atc tta caa atc ctt aca-3'
            F   G   S   L   L   G   V   C   L   I   L   Q   I   L   T


The DNA Sense Strand is shown. Amino acids are in the single-letter code. The mtDNA genetic code differs from the "universal" code.

Interchanges of pyrimidine (c t) or purine (a g) bases are transitions (Ts)
Exchanges of pyrimidine for purine (pyr pur) bases are transversions (Tv)

Note numerous third-position polymorphisms in all sequences:
        note more complex pattern at last position ( a c t)

Note second-position transversion (t a) in the Mule Deer, resulting in an isoleucine asparagine  (I N)  substitution.

Note first-position purine transition (a g) in the Moose, resulting in an isoleucine valine (I V) substitution.

Note synonymous first-position pyrimidine transitions in leu (L) codons of Moose


Text material © 2024 by Steven M. Carr