Publications

PubMed Link 

  • Díaz-Cruz GA, Liu J, Tahlan K, Bignell DRD. 2022. Nigericin and Geldanamycin Are Phytotoxic Specialized Metabolites Produced by the Plant Pathogen Streptomyces sp. 11-1-2. Microbiology Spectrum. 10(2):e0231421. doi: 10.1128/spectrum.02314-21.

  • Liu J, Nothias LF, Dorrestein PC, Tahlan K†, Bignell DRD. 2021. Genomic and Metabolomic Analysis of the Potato Common Scab Pathogen Streptomyces scabiei. ACS Omega. 6(17):11474-11487. doi: 10.1021/acsomega.1c00526.

  • Shaikh AA, Nothias LF, Srivastava SK, Dorrestein PC, Tahlan K†. 2021. Specialized Metabolites from Ribosome Engineered Strains of Streptomyces clavuligerus. Metabolites. 13;11(4):239. doi: 10.3390/metabo11040239. 

  • Schorn MA, Verhoeven S, Ridder L, Huber F, Acharya DD, Aksenov AA, Aleti G, Moghaddam JA, Aron AT, Aziz S, Bauermeister A, Bauman KD, Baunach M, Beemelmanns C, Beman JM, Berlanga-Clavero MV, Blacutt AA, Bode HB, Boullie A, Brejnrod A, Bugni TS, Calteau A, Cao L, Carrión VJ, Castelo-Branco R, Chanana S, Chase AB, Chevrette MG, Costa-Lotufo LV, Crawford JM, Currie CR, Cuypers B, Dang T, de Rond T, Demko AM, Dittmann E, Du C, Drozd C, Dujardin JC, Dutton RJ, Edlund A, Fewer DP, Garg N, Gauglitz JM, Gentry EC, Gerwick L, Glukhov E, Gross H, Gugger M, Guillén Matus DG, Helfrich EJN, Hempel BF, Hur JS, Iorio M, Jensen PR, Kang KB, Kaysser L, Kelleher NL, Kim CS, Kim KH, Koester I, König GM, Leao T, Lee SR, Lee YY, Li X, Little JC, Maloney KN, Männle D, Martin H C, McAvoy AC, Metcalf WW, Mohimani H, Molina-Santiago C, Moore BS, Mullowney MW, Muskat M, Nothias LF, O'Neill EC, Parkinson EI, Petras D, Piel J, Pierce EC, Pires K, Reher R, Romero D, Roper MC, Rust M, Saad H, Saenz C, Sanchez LM, Sørensen SJ, Sosio M, Süssmuth RD, Sweeney D, Tahlan K, Thomson RJ, Tobias NJ, Trindade-Silva AE, van Wezel GP, Wang M, Weldon KC, Zhang F, Ziemert N, Duncan KR, Crüsemann M, Rogers S, Dorrestein PC, Medema MH, van der Hooft JJJ. 2021. A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology. 17(4):363-368. doi: 10.1038/s41589-020-00724-z.

  • Byrne AS, Goudreau A, Bissonnette N, Shamputa IC and Tahlan K†. 2020. Methods for Detecting Mycobacterial Mixed Strain Infections–A Systematic Review. Frontiers in Genetics. 11:600692. doi: 10.3389/fgene.2020.600692. eCollection 2020.

  • Cheng Z, McCann S, Faraone N, Clarke J-A, Hudson EA, Cloonan K, Hillier NK and Tahlan K†. 2020. Production of Plant-Associated Volatiles by Select Model and Industrially Important Streptomyces spp. Microorganisms. 11;8(11):E1767. doi: 10.3390/microorganisms8111767. 

  • Yuting Li, Tahlan K† and Bignell DRD. 2020. Functional Cross-Talk of MbtH-Like Proteins During Thaxtomin Biosynthesis in the Potato Common Scab Pathogen Streptomyces scabiei. Frontiers in Microbiology. 11:585456. doi: 10.3389/fmicb.2020.585456. eCollection 2020.

  • Singh R, Kumar P and Tahlan K.† 2020. Drugs against M. tuberculosis. Drug Discovery Targeting Drug-Resistant Bacteria. 1: 139-170.

  • AbuSara, N.F., Piercey B.M., Moore M.A., Shaikh A.A., Nothias L.F., Srivastava S.K., Cruz-Morales P., Dorrestein P.C., Barona-Gómez F. and Tahlan K.† 2019. Comparative Genomics and Metabolomics Analyses of Clavulanic Acid-Producing Streptomyces Species Provides Insight into Specialized Metabolism. Frontiers in Microbiology. 10:2550. doi: 10.3389/fmicb.2019.02550. eCollection 2019. 

  • Li, Y., Liu, J., Adekunle, D., Bown, L., Tahlan, K.† and Bignell, D.R.D. 2019. TxtH is a key component of the thaxtomin biosynthetic machinery in the potato common scab pathogen Streptomyces scabies. Molecular Plant Pathology. doi: 10.1111/mpp.12843.

  • Srivastava, S.K. (co-1st), King, K.S. (co-1st), AbuSara, N.F., Malayny, C.J., Piercey, B.M., Wilson, J.A. and Tahlan, K.† 2019. In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus. PLoS One.14(4):e0215960. doi: 10.1371/journal.pone.0215960.  

  • Bown, L., Srivastava, S.K., Piercey, B.M., McIsaac, C.K., and Tahlan, K.† 2018. Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance. Journal of Membrane Biology. 251(1):105-117. doi: 10.1007/s00232-017-9997-3.

  • Tahlan K.†, Moore M.A. and Jensen S.E. 2017. δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase (ACVS): discovery and perspectives. Journal of Industrial Microbiology and Biotechnology. 44(4-5):517-524. doi: 10.1007/s10295-016-1850-7.

  • Davidson, F.W., Ahlstrom, C., De Buck, J., Whitney, H.G. and Tahlan, K.† 2016. Examination of Mycobacterium avium subspecies paratuberculosis mixed genotype infections in dairy animals using a whole genome sequencing approach. PeerJ 4. e2793. doi.org/10.7717/peerj.2793.

  • Ferguson, N.L., Pena-Castillo, L., Moore, M.A., Bignell, D.R.D. and Tahlan, K.† 2016. Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in Streptomyces clavuligerus. Journal of Industrial Microbiology and Biotechnology. 43(4):537-55. doi: 10.1007/s10295-016-1733-y.

  • Ahlstrom, C., Barkema H.W., Stevenson, K., Zadoks, R.N., Biek, R., Kao, R., Trewby, H., Haupstein, D., Kelton, D.F., Fecteau, G., Labrecque, O., Keefe, G.P., McKenna, S.L., Tahlan, K. and De Buck, J. 2016. Genome-Wide Diversity and Phylogeography of Mycobacterium avium subsp. paratuberculosis in Canadian Dairy Cattle. PLoS One. 12;11(2):e0149017. doi: 10.1371/journal.pone.0149017.

  • Davidson, F.W., Whitney, H.G. and Tahlan, K.† 2015. Genome sequences of Klebsiella variicola isolates from dairy animals with bovine mastitis from Newfoundland. Genome Announcements. 10;3(5): e00938-15. doi: 10.1128/genomeA.00938-15.

  • Medema M.H., Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K., Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO. 2015. The Minimum Information about a Biosynthetic Gene cluster (MIBiG) specification. Nature Chemical Biology. 11(9):625-31.

  • Podder, M.P., Banfield, S.E., Keefe, G.P., Whitney, H.G. and Tahlan, K.† 2015. Typing of Mycobacterium avium subspecies paratuberculosis isolates from Newfoundland using fragment analysis. PLoS One. 10(4): e0126071. doi: 10.1371/journal.pone.0126071.

  • Cheng Z., Bown L., Tahlan K. and Bignell D.R. 2015. Regulation of Coronafacoyl Phytotoxin Production by the PAS-LuxR Family Regulator CfaR in the Common Scab Pathogen Streptomyces scabies. PLoS One. 10(3):e0122450. doi: 10.1371/journal.pone.0122450.

  • Podder, M.P., Rogers, L., Daley, P.K., Keefe, G.P., Whitney, H.G. and Tahlan, K.† (2014). Klebsiella species associated with bovine mastitis in Newfoundland. PLoS ONE. 9(9): e106518. doi:10.1371/journal.pone.0106518.

  • Boshoff, H. and Tahlan, K. (2013) SQ-109: Treatment of tuberculosis, Cell wall biosynthesis inhibitor. Drugs of the Future. 38: 467-74.

  • Tahlan, K. and  Jensen, S.E. (2013). Origins of the β-lactam rings in natural products. The Journal of Antibiotics. 66, 401-10.

  • Kwong, T., Tahlan, K., Anders, C.L. and Jensen, S.E. (2013). Carboxyethylarginine synthase genes show complex cross regulation in Streptomyces clavuligerus. Applied and Environmental Microbiology. 79:240-9.

  • Xu, T., Willems, W., Au-yeung, C., Tahlan, K. and Nodwell, J.R. (2012) A two-step mechanism for the activation of actinorhodin export and resistance in Streptomyces coelicolor. mBio®. 2012 Oct 16;3(5). doi:pii: e00191-12. 10.1128/mBio.00191-12.

  • Kwong, T., Zelyas, N.J., Cai, H., Tahlan, K. , Wong, A. and Jensen, S.E. (2012) 5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerus. Antimicrobial Agents and Chemotherapy. 56:4845-55.

  • Tahlan, K., Wilson, R., Kastrinsky, D.B., Arora, K., Nair, V., Fischer, E., Barnes, S.W., Walker, J.R., Alland, D., Barry, C.E. 3rd and Boshoff HI. (2012) SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 56:1797-809.

  • Craney, A., Tahlan, K., Andrews, D. and Nodwell, J.( 2011) Bacterial Transmembrane Proteins that Lack N-Terminal Signal Sequences. PLoS ONE. 6(5): e19421. doi:10.1371/journal.pone.0019421

  • Backus, K.M., Boshoff, H.I., Barry, C.S., Boutureira , O., Patel, M.K., D'Hooge, F., Lee, S.S., Via, L.E., Tahlan, .K., Barry, C.E. 3rd and Davis, B.G. (2011) Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis. Nature Chemical Biology. 7: 228-35. 

  • Boshoff, H.I. and Tahlan, K. (2010) Mechanisms underlying mycobacterial infections. Drug Discovery Today: Disease Mechanisms. 7: e1–e3. (Editorial)

  • Tahlan, K., and Boshoff, H.I. (2009). New cell wall biosynthesis inhibitors under active development for TB. Drugs of the Future, 34: 739-48. (Review)

  • Zelyas, N., Tahlan, K. and Jensen S.E. (2009). Use of the native flp gene to generate in-frame unmarked mutations in Streptomyces spp. Gene. 443: 48-54.

  • Tahlan, K., Yu, Z., Yu, Y., Davidson, A.R. and Nodwell, J.R. (2008). Ligand recognition by ActR, a TetR-like regulator of actinorhodin export. Journal of Molecular Biology. 383: 753-61.

  • Boshoff, H.I., Xu, X., Tahlan, K., Dowd, C.S., Pethe, K., Camacho, L.R., Park, T.H., Yun, C.S., Schnappinger, D., Ehrt, S., Williams, K.J. and Barry, C.E. 3rd. (2008). Biosynthesis and recycling of nicotinamide cofactors in Mycobacterium tuberculosis: An essential role for NAD in non-replicating bacilli. Journal of Biological Chemistry. 283: 19329-41.

  • Willems, A.R., Tahlan, K., Taguchi, T., Zhang, K., Lee, Z.Z., Ichinose, K., Junop, M.S. and Nodwell, J.R. (2008). Crystal structures of the Streptomyces coelicolor TetR-like protein ActR alone and in complex with actinorhodin or the actinorhodin biosynthetic precursor (S)-DNPA. Journal of Molecular Biology. 376: 1377-87.

  • Ahn, S.K, Tahlan. K., Yu, Z. and Nodwell J.R. (2007). Investigation of transcription repression and small-molecule responsiveness by TetR-like transcription factors using a heterologous Escherichia coli-based assay. Journal of Bacteriology. 189: 6655-64.

  • Tahlan, K.†, Ahan, S.K., Sing, A., Bodnaruk, T., Willems, A.R., Davidson, A.R. and Nodwell, J.R. (2007). Initiation of actinorhodin export in Streptomyces coelicolor. Molecular Microbiology. 63: 951-61.(†, Received Commentary)

  • Tahlan, K., Anders, C., Wong, A., Mosher, R.H., Beatty, P.H., Brumlik, M.J., Griffin, A., Barton, B. and Jensen, S.E. (2007). 5S clavam biosynthetic genes are located in both the clavam and paralogue gene clusters in Streptomyces clavuligerus. Chemistry and Biology. 14: 131-42.

  • Bignell, D.R.D., Tahlan, K., Colvin, K.R., Jensen, S.E. and Leskiw, B.K. (2005). Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG. Antimicrobial Agents and Chemotherapy, 49: 1529-41.

  • Wang, L., Tahlan, K., Kaziuk, T.L., Alexander, D.C. and Jensen, S.E. (2004). Transcriptional and translational analysis of the ccaR gene from Streptomyces clavuligerus. Microbiology, 150: 4137-4145.

  • Tahlan, K., Anders, C. and Jensen, S.E. (2004). The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus. Journal of Bacteriology, 186: 6286-6297.

  • Tahlan, K., Park, H-U. and Jensen, S.E. (2004). Three unlinked gene clusters are involved in clavam metabolite biosynthesis in Streptomyces clavuligerus. Canadian Journal of Microbiology, 50: 803-810.

  • Tahlan, K., Park, H-U., Wong, A., Beatty, P.H. and Jensen, S.E. (2004). Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus. Antimicrobial Agents and Chemotherapy, 48: 930-939.