2022

Diaz-Cruz, G.A., Liu, J., Tahlan, K. and Bignell, D.R.D. (2022) Nigericin and geldanamycin are phytotoxic specialized metabolites produced by the plant pathogen Streptomyces sp. 11-1-2. Microbiology Spectrum In press. doi: 10.1128/spectrum.02314-21. 

Perry, H.C. and Bignell, D.R.D. (2022) Who ART thoug? ADP-ribosyltransferases and their role as virulence factors in phytopathogenic microorganisms. Canadian Journal of Plant Pathology In press.

2021

Liu, J., Nothias, L.-F., Dorrestein, P.C., Tahlan, K. and Bignell, D.R.D. (2021) Genomic and metabolomic analysis of the potato common scab pathogen Streptomyces scabiei. ACS Omega 6(17): 11474-11487. doi: 10.1021/acsomega.1c00526. 

2020

Li, Y., Tahlan, K. and Bignell, D.R.D. (2020) Functional cross-talk of MbtH-like proteins during thaxtomin biosynthesis in the potato common scab pathogen Streptomyces scabiei. Frontiers in Microbiology 11:585456. doi: 10.3389/fmicb.2020.585456. 

2019

Li, Y., Liu, J., Adekunle, D., Bown, L., Tahlan, K. and Bignell, D.R.D. (2019) TxtH is a key component of the thaxtomin biosynthetic machinery in the potato common scab pathogen Streptomyces scabies. Molecular Plant Pathology 20(10): 1379-1393. doi: 10.1111/mpp.12843.

Li, Y.†, Liu, J.†, Diaz-Cruz, G.†, Cheng, Z. and Bignell, D.R.D. (2019) Virulence mechanisms of plant-pathogenic Streptomyces species: an updated review. Microbiology 165(10): 1025-1040. doi: 10.1099/mic.0.000818 († Co-first authors)

Cheng, Z., Bown, L., Piercey, B. and Bignell, D.R.D. (2019) Positive and negative regulation of the virulence-associated coronafacoyl phytotoxin in the potato common scab pathogen Streptomyces scabies. Molecular Plant-Microbe Interactions 32(10): 1348-1359. doi: 10.1094/MPMI-03-19-0070-R

2018

Bignell, D.R.D., Cheng, Z. and Bown, L. (2018) The coronafacoyl phytotoxins: structure, biosynthesis, regulation and biological activities. Antonie Van Leeuwenhoek 111(5): 649-666. doi: 10.1007/s10482-017-1009-1

2017

Bown, L. and Bignell, D.R.D. (2017) Draft genome sequence of the plant pathogen Streptomyces sp. strain 11-1-2. Genome Announcements 5(37). pii: e00968-17. doi: 10.1128/genomeA.00968-17

Bown, L., Li, Y., Berrue, F., Verhoeven, J.T.P., Dufour, S.C. and Bignell, D.R.D. (2017) Coronafacoyl phytotoxin biosynthesis and evolution in the common scab pathogen Streptomyces scabiei. Applied and Environmental Microbiology 83(19): e01169-17. doi: 10.1128/AEM.01169-17*

* Featured in the AEM journal 'Spotlight', which highlights especially meritorious articles deemed of significant interest

Bown, L. and Bignell, D.R.D. (2017) Purification of N-coronafacoyl phytotoxins from Streptomyces scabies. Bio-protocol 7(7): e2214. doi: 10.21769/BioProtoc.2214

 

2016

Zhang, Y., Bignell, D.R.D., Zuo, R., Fan, Q., Huguet-Tapia, J.C., Ding, Y. and Loria, R. (2016) Promiscuous pathogenicity islands and phylogeny of pathogenic Streptomyces spp. Molecular Plant-Microbe Interactions 29(8): 640-650. doi: 10.1094/MPMI-04-16-0068-R

Bown, L.†, Altowairish, M.S.†, Fyans, J.K. and Bignell, D.R.D. (2016) Production of the Streptomyces scabies coronafacoyl phytotoxins involves a novel biosynthetic pathway with an F₄₂₀-dependent oxidoreductase and a short-chain dehydrogenase/reductase. Molecular Microbiology 101(1): 122-135. doi: 10.1111/mmi.13378 († Co-first authors)

Ferguson, N.L., Pena-Castillo, L., Moore, M.A., Bignell, D.R.D. and Tahlan, K. (2016) Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in Streptomyces clavuligerus. Journal of Industrial Microbiology and Biotechnology 43: 537-555. doi: 10.1007/s10295-016-1733-y

Fyans, J.K.†, Bown, L.† and Bignell, D.R.D. (2016) Isolation and characterization of plant pathogenic Streptomyces species associated with common scab – infected potato tubers in Newfoundland. Phytopathology 106(2): 123-131. doi:10.1094/PHYTO-05-15-0125-R († Co-first authors)

 

2015

Cheng, Z., Bown, L., Tahlan. K. and Bignell, D.R.D. (2015) Regulation of coronafacoyl phytotoxin production by the PAS-LuxR family regulator CfaR in the common scab pathogen Streptomyces scabies. PLOS ONE 10(3): e0122450. doi:10.1371/journal.pone.0122450 

Fyans, J.K., Altowairish, M.S., Li, Y. and Bignell, D.R.D. (2015) Characterization of the coronatine-like phytotoxins produced by the common scab pathogen Streptomyces scabies. Molecular Plant-Microbe Interactions 28(4): 443-454. doi:10.1094/MPMI-09-14-0255-R.

2014

Huguet-Tapia, J.C., Bignell, D.R.D. and Loria, R. (2014) Characterization of the integration and modular excision of the integrative conjugative element PAISt in Streptomyces turgidiscabies Car8. PLOS ONE 9(6): e99345. doi: 10.1371/journal.pone.0099345*

* Faculty of 1000 Recommended Article, K. Chater, 21 Nov 2016

Bignell, D.R.D.†, Francis, I.M.†, Fyans, J.K. and Loria, R. (2014) Thaxtomin A production and virulence are controlled by several bld gene global regulators in Streptomyces scabies. Molecular Plant-Microbe Interactions 27(8): 875-885. doi: 10.1094/MPMI-02-14-0037-R* († Co-first authors)

* Faculty of 1000 Recommended Article, K. Chater, 21 Nov 2016

Bignell, D.R.D., Fyans, J.K. and Cheng, Z. (2014) Phytotoxins produced by plant pathogenic Streptomyces species. Journal of Applied Microbiology 116: 223-235. doi: 10.1111/jam.12369 

 

2013

Fyans, J.K., Bignell, D., Loria, R., Toth, I. and Palmer, T. (2013) The ESX/type VII secretion system modulates development, but not virulence, of the plant pathogen Streptomyces scabies.  Molecular Plant Pathology 14:119-130. doi: 10.1111/j.1364-3703.2012.00835.x 

 

2010 and earlier

Bignell, D.R.D., Huguet, J.C., Joshi, M.V., Pettis, G.S. and Loria, R. (2010) What does it take to be a plant pathogen: Genomic insights from Streptomyces species. Antonie van Leeuwenhoek 98: 179-194. doi: 10.1007/s10482-010-9429-1

Bignell, D.R.D., Seipke, R.F., Chambers, A., Parry, R.J. and Loria, R. (2009) Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions. Molecular Plant-Microbe Interactions 23: 161-175. doi: 10.1094/MPMI-23-2-0161

Johnson, E.G.†, Krasnoff, S.B.†, Bignell, D.R.D.†, Chung, W.-C., Tao, T., Parry, R.J., Loria, R. and Gibson, D.M. (2009) 4-Nitrotryptophan is a substrate for the non-ribosomal peptide synthetase TxtB in the thaxtomin A biosynthetic pathway. Molecular Microbiology 73: 409-418. doi: 0.1111/j.1365-2958.2009.06780.x († Co-first authors)

Parashar, A., Colvin, K.R., Bignell, D.R.D. and Leskiw, B.K. (2009) BldG and SCO3548 interact antagonistically to control key developmental processes in Streptomyces coelicolor. Journal of Bacteriology 191: 2541-2550. doi: 10.1128/JB.01695-08

Loria, R., Bignell, D.R.D., Moll, S., Huguet-Tapia, J.C., Joshi, M.V., Johnson, E.G., Seipke, R.F. and Gibson, D.M. (2008). Thaxtomin biosynthesis: The path to plant pathogenicity in the genus Streptomyces. Antonie van Leeuwenhoek 94: 3-10. doi: 10.1007/s10482-008-9240-4

Joshi, M.V., Bignell, D.R.D., Johnson, E.J., Sparks, J.P., Gibson, D.M. and Loria, R. (2007). The AraC/XylS regulator TxtR modulates thaxtomin biosynthesis and virulence in Streptomyces scabies. Molecular Microbiology 66(3): 633-642. doi: 10.1111/j.1365-2958.2007.05942.x*

* Evaluated by Steven Busby, Faculty of 1000 Biology, 15 Nov 2007 http://www.f1000biology.com/article/id/1094984

Bignell, D.R.D., Bate, N. and Cundliffe, E. (2007). Regulation of tylosin production: role of a TylP-interactive ligand. Molecular Microbiology 63(3): 838-847. doi: 10.1111/j.1365-2958.2006.05541.x

Bate, N., Bignell, D.R.D. and Cundliffe, E. (2006). Regulation of tylosin biosynthesis involving ‘SARP-helper’ activity. Molecular Microbiology 62(1): 148-156. doi: 10.1111/j.1365-2958.2006.05338.x

Bignell, D.R.D.†, Tahlan, K.†, Colvin, K.R., Jensen, S.E. and Leskiw, B.K. (2005). Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG. Antimicrobial Agents and Chemotherapy 49: 1529-1541. doi: 10.1128/AAC.49.4.1529-1541.2005 († Co-first authors)

Bignell, D.R.D., Lau, L.H., Colvin, K.R. and Leskiw, B.K. (2003). The putative anti-anti-sigma factor BldG is post-translationally modified by phosphorylation in Streptomyces coelicolor.FEMS Microbiology Letters 225: 93-99. doi: 10.1016/S0378-1097(03)00504-4 

Bignell, D.R.D., Warawa, J.L., Strap, J.L., Chater, K.F., and Leskiw, B.K. (2000). Study of the bldG locus suggests that an anti-anti-sigma factor and an anti-sigma factor may be involved in Streptomyces coelicolor antibiotic production and sporulation. Microbiology 146: 2161-2173. doi: 10.1099/00221287-146-9-2161