Altered insulin’s control of energy metabolism in the failing heart

Qutuba Karwi, PhD
Assistant Professor
Division of BioMedical Sciences, Faculty of Medicine

Date: November 4, 2024
Time: 1:00 p.m. to 2:00 p.m. 
Room: CSF 1302

Abstract:

Alterations in cardiac energy metabolism contribute to the severity of heart failure. However, the energy metabolic changes that occur in heart failure are complex and are dependent not only on the severity and type of heart failure present but also on the co-existence of common comorbidities such as obesity and type 2 diabetes. The failing heart faces an energy deficit primarily because of a decreased mitochondrial oxidative capacity. One of the major metabolic alterations in the failing heart is the reduction in the heart’s responsiveness to insulin. This talk will discuss the impact of insulin resistance on the failing heart.