The Impact of Vitamin D, Docosahexaenoic Acid (DHA), and Co-supplementation of Vitamin D and DHA on Vitamin D Metabolism in Diet-Induced Obesity (DIO) Rat Models

Narges Ghorbani Bavani
PhD Student 
Department of Biochemistry

Date: October 7, 2024
Time: 1:00 p.m. to 2:00 p.m. 
Room: CSF 1302

Abstract:

Obesity is a growing health concern globally and is associated with numerous metabolic complications. Recent evidence suggests the risk of vitamin D deficiency in obesity state. Excess fat accumulation may cause vitamin D sequestration, leading to lower vitamin D levels. Recent studies also showed that vitamin D deficiency may impact the expression of the nuclear factors and genes involved in lipogenesis and lipolysis. Additionally, docosahexaenoic acid (DHA), an omega-3 fatty acid, may reduce fat mass accumulation via alterations in genes involved in lipogenesis and lipolysis. Moreover, it may reduce inflammation by decreasing the production of pro-inflammatory cytokines like IL-6 and TNF-α. Therefore, DHA may correct vitamin D metabolism by reducing fat accumulation and modulating genes involved in lipid metabolism. This study aims first to assess the effects of a high-fat diet on vitamin D metabolism in male and female Sprague-Dawley rats.  We then investigate the impacts of dietary DHA, vitamin D, and DHA and vitamin D co-supplementation on vitamin D metabolism in DIO animal models.