Education:

• 1990 Post-doctoral Fellow, Dept. Biochemistry, University of Alberta.
• 1984 Ph.D. University of Birmingham, UK.

Academic Appointments:

1990 Assistant Professor, Dept. Biochemistry, Memorial University.                    2021 Honorary Research Professor, Dept. Biochemistry, Memorial University.

 

Publications (selected)

Heeley, Belknap, Atherton, Hasan and White (2024). Effect of the N-terminal extension in myosin essential light chain A1 on the mechanism of actomyosin ATP hydrolysis. J. Biol. Chem 300 (1) 105521.

Silva and Heeley (2021). Existence in the actin world of a specialized slow skeletal muscle isoform. Comp. Biochem. Physiol (B) 254, 110568.

Silva, Kennedy, Hasan, Cohen and Heeley (2020). Demonstration of beta tropomyosin in Atlantic salmon. Comp. Biochem. Physiol. (B), 245, 11043.

Silva, Goonasekara, Hayley and Heeley (2020). Further investigation into the biochemical effects of phosphorylation of tropomyosin Tpm1.1. Serine-283 is in communication with the mid-region. Biochemistry 59, 4725 – 4734.

Silva, Ige, Goonasekara and Heeley (2020). Threonine-77 is a determinant of the low temperature conditioning of the most abundant isoform of tropomyosin in Atlantic salmon. Biochemistry 59, 2859 – 2869.

Heeley, White and Taylor (2019). Investigation into the mechanism of thin filament regulation by transient kinetics and equilibrium binding: Is there a conflict? J. Gen Physiol. 151, 628 – 634.

Risi, Eisner, Belknap, Heeley, White, Schröder and Galkin (2017).
Ca2+-induced Movement of Tropomyosin on Native Cardiac Thin Filaments Revealed by Cryo Electron Microscopy. Proc. Natl. Acad. Sci. 114, 6782 - 6787

Lohmeier-Vogel and Heeley (2016). Biochemical Comparison of Tpm1.1 (alpha) and Tpm2.2 (beta) Tropomyosins from Rabbit Skeletal Muscle.  Biochemistry 55, 1418 - 1427.

Fudge and Heeley (2015). Biochemical characterization of the roles of glycines-24 and 27 and threonine-179 in tropomyosin from the fast skeletal trunk muscle of Atlantic salmon. Biochemistry 54, 2769 – 2776.

(Houmeida / Heeley)*, Belknap and White (2010). Mechanism of regulation of native cardiac thin filaments by rigor cardiac myosin S1 & Ca(II).     J. Biol. Chem. 285, 32760 – 32769.

Heeley, Belknap and White (2006). Maximal activation of thin filaments requires both rigor myosin S1 and calcium. J. Biol. Chem. 281, 668 – 676.

Heeley, Belknap and White (2002). Mechanism of regulation of Pi dissociation from actomyosin-ADP-Pi by thin filament. Proc. Natl. Acad. Sci. 99, 16731 –  36.

 

Seminars (selected)

100 years of enzymes as proteins - the James Sumner story (forthcoming)

Effect of myosin essential light chains (A1 and A2) on actomyosin kinetics (2019)

The tubulin code is a traffic controller (2016)

Phosphorylation of the muscle protein tropomyosin (2015)

Interview workshop - for undergraduates (2013)

Life in (and out) of Graduate School (2011)

Cyclotides - protein circles (2009)

Fred Sanger and the sequencing of insulin (2008)

D-amino acids on the rise (2005)

Discovery of an actin isoform specific to slow muscle (2004)

Amino acids: past, present and future (2003)